G Protein-coupled Receptors: Structure- and Function-based Drug Discovery

Overview

Journal Signal Transduct Target Ther

Specialties Cell Biology
Pharmacology

Date 2021 Jan 8

PMID 33414387

Citations 192

Authors

Dehua Yang

Qingtong Zhou

Viktorija Labroska

Shanshan Qin

Sanaz Darbalaei

Yiran Wu

Elita Yuliantie

Linshan Xie

Houchao Tao

Jianjun Cheng

Qing Liu

Suwen Zhao

Wenqing Shui

Yi Jiang

Ming-Wei Wang

Affiliations

Soon will be listed here.

Abstract

As one of the most successful therapeutic target families, G protein-coupled receptors (GPCRs) have experienced a transformation from random ligand screening to knowledge-driven drug design. We are eye-witnessing tremendous progresses made recently in the understanding of their structure-function relationships that facilitated drug development at an unprecedented pace. This article intends to provide a comprehensive overview of this important field to a broader readership that shares some common interests in drug discovery.

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