Electrospinning and 3D Bioprinting for Intervertebral Disc Tissue Engineering

Overview

Journal JOR Spine

Specialty Orthopedics

Date 2021 Jan 4

PMID 33392454

Citations 12

Authors

Andrea De Pieri

Ann M Byerley

Catherine R Musumeci

Fatemeh Salemizadehparizi

Maya A Vanderhorst

Karin Wuertz-Kozak

Affiliations

Soon will be listed here.

Abstract

Intervertebral disc (IVD) degeneration is a major cause of low back pain and represents a massive socioeconomic burden. Current conservative and surgical treatments fail to restore native tissue architecture and functionality. Tissue engineering strategies, especially those based on 3D bioprinting and electrospinning, have emerged as possible alternatives by producing cell-seeded scaffolds that replicate the structure of the IVD extracellular matrix. In this review, we provide an overview of recent advancements and limitations of 3D bioprinting and electrospinning for the treatment of IVD degeneration, focusing on future areas of research that may contribute to their clinical translation.

Citing Articles

From structure to therapy: the critical influence of cartilaginous endplates and microvascular network on intervertebral disc degeneration.

Sun Y, Li Z, Duan J, Liu E, Yang L, Sun F Front Bioeng Biotechnol. 2024; 12:1489420.

PMID: 39530056 PMC: 11550963. DOI: 10.3389/fbioe.2024.1489420.

Three-dimensional breast cancer tumor models based on natural hydrogels: a review.

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Cutting-Edge Biomaterials in Intervertebral Disc Degeneration Tissue Engineering.

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From hyperglycemia to intervertebral disc damage: exploring diabetic-induced disc degeneration.

Li S, Du J, Huang Y, Gao S, Zhao Z, Chang Z Front Immunol. 2024; 15:1355503.

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Cartilaginous endplates: A comprehensive review on a neglected structure in intervertebral disc research.

Crump K, Alminnawi A, Bermudez-Lekerika P, Compte R, Gualdi F, McSweeney T JOR Spine. 2023; 6(4):e1294.

PMID: 38156054 PMC: 10751983. DOI: 10.1002/jsp2.1294.

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