Towards the Scale Up of Tissue Engineered Intervertebral Discs for Clinical Application

Overview

Journal Acta Biomater

Publisher Elsevier

Specialty Biomedical Engineering

Date 2018 Feb 11

PMID 29427744

Citations 11

Authors

Sarah E Gullbrand

Dong Hwa Kim

Edward Bonnevie

Beth G Ashinsky

Lachlan J Smith

Dawn M Elliott

Robert L Mauck

Harvey E Smith

Affiliations

Soon will be listed here.

Abstract

Statement Of Significance: This work establishes, for the first time, tissue-engineered intervertebral discs for total disc replacement at large, clinically relevant length scales. Clinical translation of tissue-engineered discs will offer an alternative to mechanical disc arthroplasty and fusion procedures, and may contribute to a paradigm shift in the clinical care for patients with disc pathology and associated axial spine and neurogenic extremity pain.

Citing Articles

Restoration of physiologic loading after engineered disc implantation mitigates immobilization-induced facet joint and paraspinal muscle degeneration.

Gullbrand S, Kiapour A, Barrett C, Fainor M, Orozco B, Hilliard R Acta Biomater. 2024; 192():128-139.

PMID: 39653318 PMC: 11735281. DOI: 10.1016/j.actbio.2024.12.014.

Current Therapeutic Strategies of Intervertebral Disc Regenerative Medicine.

Elmounedi N, Bahloul W, Keskes H Mol Diagn Ther. 2024; 28(6):745-775.

PMID: 39158834 DOI: 10.1007/s40291-024-00729-7.

The role of biomechanical factors in models of intervertebral disc degeneration across multiple length scales.

Lazaro-Pacheco D, Mohseni M, Rudd S, Cooper-White J, Holsgrove T APL Bioeng. 2023; 7(2):021501.

PMID: 37180733 PMC: 10168717. DOI: 10.1063/5.0137698.

A Tunable Calcium Phosphate Coating to Drive in vivo Osseointegration of Composite Engineered Tissues.

Fainor M, Mahindroo S, Betz K, Augustin J, Smith H, Mauck R Cells Tissues Organs. 2023; 212(5):383-398.

PMID: 36966531 PMC: 10616759. DOI: 10.1159/000528965.

Ion elemental-optimized layered double hydroxide nanoparticles promote chondrogenic differentiation and intervertebral disc regeneration of mesenchymal stem cells through focal adhesion signaling pathway.

Wang Z, Yang H, Xu X, Hu H, Bai Y, Hai J Bioact Mater. 2022; 22:75-90.

PMID: 36203960 PMC: 9520222. DOI: 10.1016/j.bioactmat.2022.08.023.

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