Bacterial Nanocellulose in Dentistry: Perspectives and Challenges

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2020 Dec 30

PMID 33374301

Citations 12

Authors

Helida Gomes de Oliveira Barud

Robson Rosa da Silva

Marco Antonio Costa Borges

Guillermo Raul Castro

Sidney Jose Lima Ribeiro

Hernane da Silva Barud

Affiliations

Soon will be listed here.

Abstract

Bacterial cellulose (BC) is a natural polymer that has fascinating attributes, such as biocompatibility, low cost, and ease of processing, being considered a very interesting biomaterial due to its options for moldability and combination. Thus, BC-based compounds (for example, BC/collagen, BC/gelatin, BC/fibroin, BC/chitosan, etc.) have improved properties and/or functionality, allowing for various biomedical applications, such as artificial blood vessels and microvessels, artificial skin, and wounds dressing among others. Despite the wide applicability in biomedicine and tissue engineering, there is a lack of updated scientific reports on applications related to dentistry, since BC has great potential for this. It has been used mainly in the regeneration of periodontal tissue, surgical dressings, intraoral wounds, and also in the regeneration of pulp tissue. This review describes the properties and advantages of some BC studies focused on dental and oral applications, including the design of implants, scaffolds, and wound-dressing materials, as well as carriers for drug delivery in dentistry. Aligned to the current trends and biotechnology evolutions, BC-based nanocomposites offer a great field to be explored and other novel features can be expected in relation to oral and bone tissue repair in the near future.

Citing Articles

Applications and interventions of polymers and nanomaterials in alveolar bone regeneration and tooth dentistry.

Sharma P, Saurav S, Tabassum Z, Sood B, Kumar A, Malik T RSC Adv. 2024; 14(49):36226-36245.

PMID: 39534053 PMC: 11555558. DOI: 10.1039/d4ra06092j.

Sustained antibacterial activity of orthodontic elastomeric ligature ties coated with a novel kombucha-derived bacterial nanocellulose: An in-vitro study.

Eskandari F, Borzou S, Razavian A, Babanouri N, Yousefi K PLoS One. 2024; 19(2):e0292966.

PMID: 38329966 PMC: 10852283. DOI: 10.1371/journal.pone.0292966.

Influence of the Synthesis Scheme of Nanocrystalline Cerium Oxide and Its Concentration on the Biological Activity of Cells Providing Wound Regeneration.

Silina E, Stupin V, Manturova N, Ivanova O, Popov A, Mysina E Int J Mol Sci. 2023; 24(19).

PMID: 37833949 PMC: 10572590. DOI: 10.3390/ijms241914501.

Fungal Carboxymethyl Chitosan-Impregnated Bacterial Cellulose Hydrogel as Wound-Dressing Agent.

Suneetha M, Won S, Zo S, Han S Gels. 2023; 9(3).

PMID: 36975633 PMC: 10048145. DOI: 10.3390/gels9030184.

Nanomaterials in Scaffolds for Periodontal Tissue Engineering: Frontiers and Prospects.

Chen S, Huang X Bioengineering (Basel). 2022; 9(9).

PMID: 36134977 PMC: 9495816. DOI: 10.3390/bioengineering9090431.

References

Verma P, Srivastava R, Gupta K, Chaturvedi T . Treatment strategy for guided tissue regeneration in various class II furcation defect: Case series. Dent Res J (Isfahan). 2013; 10(5):689-94. PMC: 3858748. View

Trovatti E, Freire C, Pinto P, Almeida I, Costa P, Silvestre A . Bacterial cellulose membranes applied in topical and transdermal delivery of lidocaine hydrochloride and ibuprofen: in vitro diffusion studies. Int J Pharm. 2012; 435(1):83-7. DOI: 10.1016/j.ijpharm.2012.01.002. View

Trovatti E, Silva N, Duarte I, Rosado C, Almeida I, Costa P . Biocellulose membranes as supports for dermal release of lidocaine. Biomacromolecules. 2011; 12(11):4162-8. DOI: 10.1021/bm201303r. View

Chiu L, Weisel R, Li R, Radisic M . Defining conditions for covalent immobilization of angiogenic growth factors onto scaffolds for tissue engineering. J Tissue Eng Regen Med. 2010; 5(1):69-84. DOI: 10.1002/term.292. View

Barud H, de Araujo Junior A, Saska S, Mestieri L, Campos J, de Freitas R . Antimicrobial Brazilian Propolis (EPP-AF) Containing Biocellulose Membranes as Promising Biomaterial for Skin Wound Healing. Evid Based Complement Alternat Med. 2013; 2013:703024. PMC: 3690832. DOI: 10.1155/2013/703024. View

Muller A, Ni Z, Hessler N, Wesarg F, Muller F, Kralisch D . The biopolymer bacterial nanocellulose as drug delivery system: investigation of drug loading and release using the model protein albumin. J Pharm Sci. 2012; 102(2):579-92. DOI: 10.1002/jps.23385. View

Wan Y, Gao C, Luo H, He F, Liang H, Li X . Early growth of nano-sized calcium phosphate on phosphorylated bacterial cellulose nanofibers. J Nanosci Nanotechnol. 2009; 9(11):6494-500. DOI: 10.1166/jnn.2009.1311. View

de Oliveira Barud H, da Silva R, Barud H, Tercjak A, Gutierrez J, Lustri W . A multipurpose natural and renewable polymer in medical applications: Bacterial cellulose. Carbohydr Polym. 2016; 153:406-420. DOI: 10.1016/j.carbpol.2016.07.059. View

Koike T, Sha J, Bai Y, Matsuda Y, Hideshima K, Yamada T . Efficacy of Bacterial Cellulose as a Carrier of BMP-2 for Bone Regeneration in a Rabbit Frontal Sinus Model. Materials (Basel). 2019; 12(15). PMC: 6696112. DOI: 10.3390/ma12152489. View

10.

Saska S, Barud H, Gaspar A, Marchetto R, Ribeiro S, Messaddeq Y . Bacterial cellulose-hydroxyapatite nanocomposites for bone regeneration. Int J Biomater. 2011; 2011:175362. PMC: 3180784. DOI: 10.1155/2011/175362. View

11.

Stoica-Guzun A, Stroescu M, Jinga S, Jipa I, Dobre T, Dobre L . Ultrasound influence upon calcium carbonate precipitation on bacterial cellulose membranes. Ultrason Sonochem. 2012; 19(4):909-15. DOI: 10.1016/j.ultsonch.2011.12.002. View

12.

Klemm D, Heublein B, Fink H, Bohn A . Cellulose: fascinating biopolymer and sustainable raw material. Angew Chem Int Ed Engl. 2005; 44(22):3358-93. DOI: 10.1002/anie.200460587. View

13.

Yoshino A, Tabuchi M, Uo M, Tatsumi H, Hideshima K, Kondo S . Applicability of bacterial cellulose as an alternative to paper points in endodontic treatment. Acta Biomater. 2012; 9(4):6116-22. DOI: 10.1016/j.actbio.2012.12.022. View

14.

Xu C, Su P, Chen X, Meng Y, Yu W, Xiang A . Biocompatibility and osteogenesis of biomimetic Bioglass-Collagen-Phosphatidylserine composite scaffolds for bone tissue engineering. Biomaterials. 2010; 32(4):1051-8. DOI: 10.1016/j.biomaterials.2010.09.068. View

15.

Needleman I, Worthington H, Giedrys-Leeper E, Tucker R . Guided tissue regeneration for periodontal infra-bony defects. Cochrane Database Syst Rev. 2006; (2):CD001724. DOI: 10.1002/14651858.CD001724.pub2. View

16.

Grande C, Torres F, Gomez C, Bano M . Nanocomposites of bacterial cellulose/hydroxyapatite for biomedical applications. Acta Biomater. 2009; 5(5):1605-15. DOI: 10.1016/j.actbio.2009.01.022. View

17.

Coelho F, Cavicchioli M, Specian S, Scarel-Caminaga R, de Aquino Penteado L, de Medeiros A . Bacterial cellulose membrane functionalized with hydroxiapatite and anti-bone morphogenetic protein 2: A promising material for bone regeneration. PLoS One. 2019; 14(8):e0221286. PMC: 6699690. DOI: 10.1371/journal.pone.0221286. View

18.

Fontana J, De Souza A, Fontana C, Torriani I, Moreschi J, Gallotti B . Acetobacter cellulose pellicle as a temporary skin substitute. Appl Biochem Biotechnol. 1990; 24-25:253-64. DOI: 10.1007/BF02920250. View

19.

Ma P . Biomimetic materials for tissue engineering. Adv Drug Deliv Rev. 2007; 60(2):184-98. PMC: 2271038. DOI: 10.1016/j.addr.2007.08.041. View

20.

Czaja W, Young D, Kawecki M, Brown Jr R . The future prospects of microbial cellulose in biomedical applications. Biomacromolecules. 2007; 8(1):1-12. DOI: 10.1021/bm060620d. View