Classical and Alternative Receptors for SARS-CoV-2 Therapeutic Strategy

Overview

Journal Rev Med Virol

Publisher Wiley

Specialty Microbiology

Date 2020 Dec 28

PMID 33368788

Citations 38

Authors

Siti Fathiah Masre

Nurul Farhana Jufri

Farah Wahida Ibrahim

Sayyidi Hamzi Abdul Raub

Affiliations

Soon will be listed here.

Abstract

Understanding the molecules that are essential for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) entry can provide insights into viral infection and dissemination. Recently, it has been identified from several studies that angiotensin-converting enzyme 2 receptor and transmembrane serine protease 2 are the main entry molecules for the SARS-CoV-2, which produced the pandemic of Covid-19. However, additional evidence showed several other viral receptors and cellular proteases that are also important in facilitating viral entry and transmission in the target cells. In this review, we summarized the types of SARS-CoV-2 entry molecules and discussed their crucial roles for virus binding, protein priming and fusion to the cellular membrane important for SARS-CoV-2 infection.

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