Neuropilins: Expression and Roles in the Epithelium

Overview

Journal Int J Exp Pathol

Publisher Wiley

Specialty Pathology

Date 2012 Mar 15

PMID 22414290

Citations 71

Authors

Jonathan R L Wild

Carolyn A Staton

Keith Chapple

Bernard M Corfe

Affiliations

Soon will be listed here.

Abstract

Initially found expressed in neuronal and then later in endothelial cells, it is well established that the transmembrane glycoproteins neuropilin-1 (NRP1) and neuropilin-2 (NRP2) play essential roles in axonal growth and guidance and in physiological and pathological angiogenesis. Neuropilin expression and function in epithelial cells has received little attention when compared with neuronal and endothelial cells. Overexpression of NRPs is shown to enhance growth, correlate with invasion and is associated with poor prognosis in various tumour types, especially those of epithelial origin. The contribution of NRP and its ligands to tumour growth and metastasis has spurred a strong interest in NRPs as novel chemotherapy drug targets. Given NRP's role as a multifunctional co-receptor with an ability to bind with disparate ligand families, this has sparked new areas of research implicating NRPs in diverse biological functions. Here, we review the growing body of research demonstrating NRP expression and role in the normal and neoplastic epithelium.

Citing Articles

Leveraging Artificial Intelligence and Gene Expression Analysis to Identify Some Potential Bovine Coronavirus (BCoV) Receptors and Host Cell Enzymes Potentially Involved in the Viral Replication and Tissue Tropism.

Khan M, Shah A, Duraisamy N, ElAlaoui R, Cherkaoui M, Hemida M Int J Mol Sci. 2025; 26(3).

PMID: 39941096 PMC: 11818245. DOI: 10.3390/ijms26031328.

Human cytomegalovirus: pathogenesis, prevention, and treatment.

Shang Z, Li X Mol Biomed. 2024; 5(1):61.

PMID: 39585514 PMC: 11589059. DOI: 10.1186/s43556-024-00226-7.

Differential modulation of cell morphology, migration, and Neuropilin-1 expression in cancer and non-cancer cell lines by substrate stiffness.

Vela-Alcantara A, Santiago-Garcia J, Barragan-Palacios M, Leon-Chacon A, Dominguez-Pantoja M, Barceinas-Davila I Front Cell Dev Biol. 2024; 12:1352233.

PMID: 38903533 PMC: 11188430. DOI: 10.3389/fcell.2024.1352233.

Specific lineage transition of tumor-associated macrophages elicits immune evasion of ascitic tumor cells in gastric cancer with peritoneal metastasis.

Li Y, Jiang L, Chen Y, Li Y, Yuan J, Lu J Gastric Cancer. 2024; 27(3):519-538.

PMID: 38460015 PMC: 11016508. DOI: 10.1007/s10120-024-01486-6.

Biophysical investigation of interactions between SARS-CoV-2 spike protein and neuropilin-1.

Hou D, Cao W, Kim S, Cui X, Ziarnik M, Im W Protein Sci. 2023; 32(10):e4773.

PMID: 37656811 PMC: 10510470. DOI: 10.1002/pro.4773.

References

Sanchez-Carbayo M, Socci N, Lozano J, Li W, Charytonowicz E, Belbin T . Gene discovery in bladder cancer progression using cDNA microarrays. Am J Pathol. 2003; 163(2):505-16. PMC: 1868230. DOI: 10.1016/S0002-9440(10)63679-6. View

Cai H, Reed R . Cloning and characterization of neuropilin-1-interacting protein: a PSD-95/Dlg/ZO-1 domain-containing protein that interacts with the cytoplasmic domain of neuropilin-1. J Neurosci. 1999; 19(15):6519-27. PMC: 6782790. View

Cohen T, Herzog Y, Brodzky A, Greenson J, Eldar S, Gluzman-Poltorak Z . Neuropilin-2 is a novel marker expressed in pancreatic islet cells and endocrine pancreatic tumours. J Pathol. 2002; 198(1):77-82. DOI: 10.1002/path.1179. View

Kanellis J, Fraser S, Katerelos M, Power D . Vascular endothelial growth factor is a survival factor for renal tubular epithelial cells. Am J Physiol Renal Physiol. 2000; 278(6):F905-15. DOI: 10.1152/ajprenal.2000.278.6.F905. View

Serini G, Valdembri D, Zanivan S, Morterra G, Burkhardt C, Caccavari F . Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function. Nature. 2003; 424(6947):391-7. DOI: 10.1038/nature01784. View

Llovet J, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc J . Sorafenib in advanced hepatocellular carcinoma. N Engl J Med. 2008; 359(4):378-90. DOI: 10.1056/NEJMoa0708857. View

Pellet-Many C, Frankel P, Jia H, Zachary I . Neuropilins: structure, function and role in disease. Biochem J. 2008; 411(2):211-26. DOI: 10.1042/BJ20071639. View

Reidy K, Villegas G, Teichman J, Veron D, Shen W, Jimenez J . Semaphorin3a regulates endothelial cell number and podocyte differentiation during glomerular development. Development. 2009; 136(23):3979-89. PMC: 2778745. DOI: 10.1242/dev.037267. View

Antipenko A, Himanen J, van Leyen K, Nardi-Dei V, Lesniak J, Barton W . Structure of the semaphorin-3A receptor binding module. Neuron. 2003; 39(4):589-98. DOI: 10.1016/s0896-6273(03)00502-6. View

10.

Gerber H, Hillan K, Ryan A, Kowalski J, Keller G, RANGELL L . VEGF is required for growth and survival in neonatal mice. Development. 1999; 126(6):1149-59. DOI: 10.1242/dev.126.6.1149. View

11.

Drenberg C, Livingston S, Chen R, Kruk P, Nicosia S . Expression of Semaphorin 3F and Its Receptors in Epithelial Ovarian Cancer, Fallopian Tubes, and Secondary Müllerian Tissues. Obstet Gynecol Int. 2009; 2009:730739. PMC: 2796214. DOI: 10.1155/2009/730739. View

12.

Perala N, Jakobson M, Ola R, Fazzari P, Penachioni J, Nymark M . Sema4C-Plexin B2 signalling modulates ureteric branching in developing kidney. Differentiation. 2010; 81(2):81-91. DOI: 10.1016/j.diff.2010.10.001. View

13.

Yamaguchi J, Nakamura F, Aihara M, Yamashita N, Usui H, Hida T . Semaphorin3A alleviates skin lesions and scratching behavior in NC/Nga mice, an atopic dermatitis model. J Invest Dermatol. 2008; 128(12):2842-9. DOI: 10.1038/jid.2008.150. View

14.

Straume O, Akslen L . Increased expression of VEGF-receptors (FLT-1, KDR, NRP-1) and thrombospondin-1 is associated with glomeruloid microvascular proliferation, an aggressive angiogenic phenotype, in malignant melanoma. Angiogenesis. 2004; 6(4):295-301. DOI: 10.1023/B:AGEN.0000029408.08638.aa. View

15.

Nguyen Q, Rodrigues S, Rodrigue C, Rivat C, Grijelmo C, Bruyneel E . Inhibition of vascular endothelial growth factor (VEGF)-165 and semaphorin 3A-mediated cellular invasion and tumor growth by the VEGF signaling inhibitor ZD4190 in human colon cancer cells and xenografts. Mol Cancer Ther. 2006; 5(8):2070-7. DOI: 10.1158/1535-7163.MCT-06-0044. View

16.

Straub R, Grum F, Strauch U, Capellino S, Bataille F, Bleich A . Anti-inflammatory role of sympathetic nerves in chronic intestinal inflammation. Gut. 2008; 57(7):911-21. DOI: 10.1136/gut.2007.125401. View

17.

Gray M, Van Buren G, Dallas N, Xia L, Wang X, Yang A . Therapeutic targeting of neuropilin-2 on colorectal carcinoma cells implanted in the murine liver. J Natl Cancer Inst. 2008; 100(2):109-20. DOI: 10.1093/jnci/djm279. View

18.

Evans I, Yamaji M, Britton G, Pellet-Many C, Lockie C, Zachary I . Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells. Mol Cell Biol. 2011; 31(6):1174-85. PMC: 3067908. DOI: 10.1128/MCB.00903-10. View

19.

Hu B, Guo P, Bar-Joseph I, Imanishi Y, Jarzynka M, Bogler O . Neuropilin-1 promotes human glioma progression through potentiating the activity of the HGF/SF autocrine pathway. Oncogene. 2007; 26(38):5577-86. PMC: 2846324. DOI: 10.1038/sj.onc.1210348. View

20.

Serini G, Maione F, Giraudo E, Bussolino F . Semaphorins and tumor angiogenesis. Angiogenesis. 2009; 12(2):187-93. DOI: 10.1007/s10456-009-9138-4. View