MR1-Restricted T Cells with MAIT-like Characteristics Are Functionally Conserved in the Pteropid Bat

Overview

Journal iScience

Publisher Cell Press

Date 2020 Dec 21

PMID 33344919

Citations 13

Authors

Edwin Leeansyah

Ying Ying Hey

Wan Rong Sia

Justin Han Jia Ng

Muhammad Yaaseen Gulam

Caroline Boulouis

Feng Zhu

Matae Ahn

Jeffrey Y W Mak

David P Fairlie

Andrea Lay Hoon Kwa

Johan K Sandberg

Lin-Fa Wang

Affiliations

Soon will be listed here.

Abstract

Bats are reservoirs for a large number of viruses which have potential to cause major human disease outbreaks, including the current coronavirus disease 2019 (COVID-19) pandemic. Major efforts are underway to understand bat immune response to viruses, whereas much less is known about their immune responses to bacteria. In this study, MR1-restricted T (MR1T) cells were detected through the use of MR1 tetramers in circulation and tissues of (Pa) bats. Pa MR1T cells exhibited weak responses to MR1-presented microbial metabolites at resting state. However, following priming with MR1-presented agonist they proliferated, upregulated critical transcription factors and cytolytic proteins, and gained transient expression of Th1/17-related cytokines and antibacterial cytotoxicity. Collectively, these findings show that the Pa bat immune system encompasses an abundant and functionally conserved population of MR1T cells with mucosal-associated invariant T-like characteristics, suggesting that MR1 and MR1T cells also play a significant role in bat immune defense.

Citing Articles

MAIT cell homing in intestinal homeostasis and inflammation.

Wu Z, Chen X, Han F, Leeansyah E Sci Adv. 2025; 11(6):eadu4172.

PMID: 39919191 PMC: 11804934. DOI: 10.1126/sciadv.adu4172.

MAIT cells: Conserved watchers on the wall.

Germain L, Veloso P, Lantz O, Legoux F J Exp Med. 2024; 222(1).

PMID: 39446132 PMC: 11514058. DOI: 10.1084/jem.20232298.

MAIT cell activation and recruitment in inflammation and tissue damage in acute appendicitis.

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PMID: 38865451 PMC: 11168461. DOI: 10.1126/sciadv.adn6331.

A conserved transcriptional program for MAIT cells across mammalian evolution.

Bugaut H, El Morr Y, Mestdagh M, Darbois A, Paiva R, Salou M J Exp Med. 2023; 221(2).

PMID: 38117256 PMC: 10733631. DOI: 10.1084/jem.20231487.

Genes, inflammatory response, tolerance, and resistance to virus infections in migratory birds, bats, and rodents.

Pereira P, Guerreiro Diniz D, da Costa E, Magalhaes N, da Silva A, Leite J Front Immunol. 2023; 14:1239572.

PMID: 37711609 PMC: 10497949. DOI: 10.3389/fimmu.2023.1239572.

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