Ultra-strong Thermoresponsive Double Network Hydrogels

Overview

Journal Soft Matter

Publisher Royal Society of Chemistry

Specialties Biochemistry
Chemistry

Date 2020 Dec 18

PMID 33335560

Citations 12

Authors

Ruochong Fei

Jason T George

Jeehyun Park

A Kristen Means

Melissa A Grunlan

Affiliations

Soon will be listed here.

Abstract

Thermoresponsive poly(-isopropylacrylamide) (PNIPAAm) hydrogels are widely studied smart materials, particularly for biomedical applications, but are limited by their mechanical strength. In this study, double network (DN) hydrogels were prepared with an asymmetric crosslink design and inclusion of an electrostatic co-monomer, 2-acrylamido-2-methylpropane sulfonic acid (AMPS). These P(NIPAAm--AMPS)/PNIPAAm DN hydrogels were sequentially formed with a tightly crosslinked 1 network comprised of variable levels of AMPS (100 : 0 to 25 : 75 wt% ratio of NIPAAm:AMPS) and a loosely crosslinked 2 network comprised of PNIPAAm. The impact of AMPS content in the 1 network on the volume phase transition temperature (VPTT), morphology, deswelling-reswelling kinetics and mechanical properties was evaluated. Without substantially altering the VPTT of conventional PNIPAAm hydrogels but with improving thermosensitivity, the DN hydrogel formed with 25 : 75 wt% of NIPAAm:AMPS achieved exceptional strength, high modulus and high %strain at break.

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References

Fei R, George J, Park J, Grunlan M . Thermoresponsive nanocomposite double network hydrogels. Soft Matter. 2013; 8(2):481-487. PMC: 3535461. DOI: 10.1039/C1SM06105D. View

Eddington D, Beebe D . Flow control with hydrogels. Adv Drug Deliv Rev. 2004; 56(2):199-210. DOI: 10.1016/j.addr.2003.08.013. View

Weng L, Gouldstone A, Wu Y, Chen W . Mechanically strong double network photocrosslinked hydrogels from N,N-dimethylacrylamide and glycidyl methacrylated hyaluronan. Biomaterials. 2008; 29(14):2153-63. PMC: 2323023. DOI: 10.1016/j.biomaterials.2008.01.012. View

Gant R, Hou Y, Grunlan M, Cote G . Development of a self-cleaning sensor membrane for implantable biosensors. J Biomed Mater Res A. 2008; 90(3):695-701. DOI: 10.1002/jbm.a.32135. View

Li Z, He Q, Ma D, Chen H, Soper S . Thermoswitchable electrokinetic ion-enrichment/elution based on a poly(N-isopropylacrylamide) hydrogel plug in a microchannel. Anal Chem. 2010; 82(24):10030-6. DOI: 10.1021/ac101768j. View

Li Z, He Q, Ma D, Chen H . On-chip integrated multi-thermo-actuated microvalves of poly(N-isopropylacrylamide) for microflow injection analysis. Anal Chim Acta. 2010; 665(2):107-12. DOI: 10.1016/j.aca.2010.03.024. View

Zhang X, Xu X, Cheng S, Zhuo R . Strategies to improve the response rate of thermosensitive hydrogels. Soft Matter. 2020; 4(3):385-391. DOI: 10.1039/b713803m. View

Zhang X, Wu D, Chu C . Synthesis, characterization and controlled drug release of thermosensitive IPN-PNIPAAm hydrogels. Biomaterials. 2004; 25(17):3793-805. DOI: 10.1016/j.biomaterials.2003.10.065. View

Myung D, Waters D, Wiseman M, Duhamel P, Noolandi J, Ta C . Progress in the development of interpenetrating polymer network hydrogels. Polym Adv Technol. 2011; 19(6):647-657. PMC: 2745247. DOI: 10.1002/pat.1134. View

10.

Bekiari V, Lianos P . Photophysical behavior of terpyridine-lanthanide ion complexes incorporated in a poly(N,N-dimethylacrylamide) hydrogel. Langmuir. 2006; 22(20):8602-6. DOI: 10.1021/la061406d. View

11.

Yasuda K, Gong J, Katsuyama Y, Nakayama A, Tanabe Y, Kondo E . Biomechanical properties of high-toughness double network hydrogels. Biomaterials. 2005; 26(21):4468-75. DOI: 10.1016/j.biomaterials.2004.11.021. View

12.

Kobayashi J, Okano T . Fabrication of a thermoresponsive cell culture dish: a key technology for cell sheet tissue engineering. Sci Technol Adv Mater. 2016; 11(1):014111. PMC: 5090553. DOI: 10.1088/1468-6996/11/1/014111. View

13.

Anseth K, Bowman C . Mechanical properties of hydrogels and their experimental determination. Biomaterials. 1996; 17(17):1647-57. DOI: 10.1016/0142-9612(96)87644-7. View

14.

Chilkoti A, Dreher M, Meyer D, Raucher D . Targeted drug delivery by thermally responsive polymers. Adv Drug Deliv Rev. 2002; 54(5):613-30. DOI: 10.1016/s0169-409x(02)00041-8. View

15.

Qiu Y, Park K . Environment-sensitive hydrogels for drug delivery. Adv Drug Deliv Rev. 2001; 53(3):321-39. DOI: 10.1016/s0169-409x(01)00203-4. View

16.

Zhang X, Yang Y, Chung T . The influence of cold treatment on properties of temperature-sensitive poly(N-isopropylacrylamide) hydrogels. J Colloid Interface Sci. 2005; 246(1):105-11. DOI: 10.1006/jcis.2001.8063. View

17.

Chaterji S, Kwon I, Park K . Smart Polymeric Gels: Redefining the Limits of Biomedical Devices. Prog Polym Sci. 2008; 32(8-9):1083-1122. PMC: 2084382. DOI: 10.1016/j.progpolymsci.2007.05.018. View

18.

Gant R, Abraham A, Hou Y, Cummins B, Grunlan M, Cote G . Design of a self-cleaning thermoresponsive nanocomposite hydrogel membrane for implantable biosensors. Acta Biomater. 2010; 6(8):2903-10. DOI: 10.1016/j.actbio.2010.01.039. View