Carbon Nanomaterials for Electro-Active Structures: A Review

Overview

Journal Polymers (Basel)

Publisher MDPI

Date 2020 Dec 15

PMID 33317211

Citations 9

Authors

Weiguang Wang

Yanhao Hou

Dean Martinez

Darwin Kurniawan

Wei-Hung Chiang

Paulo Bartolo

Affiliations

Soon will be listed here.

Abstract

The use of electrically conductive materials to impart electrical properties to substrates for cell attachment proliferation and differentiation represents an important strategy in the field of tissue engineering. This paper discusses the concept of electro-active structures and their roles in tissue engineering, accelerating cell proliferation and differentiation, consequently leading to tissue regeneration. The most relevant carbon-based materials used to produce electro-active structures are presented, and their main advantages and limitations are discussed in detail. Particular emphasis is put on the electrically conductive property, material synthesis and their applications on tissue engineering. Different technologies, allowing the fabrication of two-dimensional and three-dimensional structures in a controlled way, are also presented. Finally, challenges for future research are highlighted. This review shows that electrical stimulation plays an important role in modulating the growth of different types of cells. As highlighted, carbon nanomaterials, especially graphene and carbon nanotubes, have great potential for fabricating electro-active structures due to their exceptional electrical and surface properties, opening new routes for more efficient tissue engineering approaches.

Citing Articles

Recent advances in shape memory scaffolds and regenerative outcomes.

Valioglu F, Valipour F, Atazadeh S, Hasansadeh M, Khosrowshahi N, Nezamdoust F Biomed Eng Lett. 2024; 14(6):1279-1301.

PMID: 39465110 PMC: 11502725. DOI: 10.1007/s13534-024-00417-9.

Nanofibrous Material-Reinforced Printable Ink for Enhanced Cell Proliferation and Tissue Regeneration.

Raja I, Kim B, Han D Bioengineering (Basel). 2024; 11(4).

PMID: 38671784 PMC: 11047974. DOI: 10.3390/bioengineering11040363.

Controlled Alignment of Carbon Black Nanoparticles in Electrospun Carbon Nanofibers for Flexible Films.

Aboalhassan A, Babar A, Iqbal N, Yan J, El-Newehy M, Yu J Polymers (Basel). 2024; 16(3).

PMID: 38337216 PMC: 10857169. DOI: 10.3390/polym16030327.

Neuro-nanotechnology: diagnostic and therapeutic nano-based strategies in applied neuroscience.

Shabani L, Abbasi M, Azarnew Z, Amani A, Vaez A Biomed Eng Online. 2023; 22(1):1.

PMID: 36593487 PMC: 9809121. DOI: 10.1186/s12938-022-01062-y.

Conductive Supramolecular Polymer Nanocomposites with Tunable Properties to Manipulate Cell Growth and Functions.

Wu C, Melaku A, Ilhami F, Chiu C, Cheng C Int J Mol Sci. 2022; 23(8).

PMID: 35457150 PMC: 9032009. DOI: 10.3390/ijms23084332.

References

Ku S, Lee M, Park C . Carbon-based nanomaterials for tissue engineering. Adv Healthc Mater. 2012; 2(2):244-60. DOI: 10.1002/adhm.201200307. View

Jachak A, Creighton M, Qiu Y, Kane A, Hurt R . Biological interactions and safety of graphene materials. MRS Bull. 2014; 37(12):1307-1313. PMC: 4088959. DOI: 10.1557/mrs.2012.181. View

Novoselov K, Geim A, Morozov S, Jiang D, Zhang Y, Dubonos S . Electric field effect in atomically thin carbon films. Science. 2004; 306(5696):666-9. DOI: 10.1126/science.1102896. View

Fu C, Pan S, Ma Y, Kong W, Qi Z, Yang X . Effect of electrical stimulation combined with graphene-oxide-based membranes on neural stem cell proliferation and differentiation. Artif Cells Nanomed Biotechnol. 2019; 47(1):1867-1876. DOI: 10.1080/21691401.2019.1613422. View

Kharaziha M, Shin S, Nikkhah M, Topkaya S, Masoumi N, Annabi N . Tough and flexible CNT-polymeric hybrid scaffolds for engineering cardiac constructs. Biomaterials. 2014; 35(26):7346-54. PMC: 4114042. DOI: 10.1016/j.biomaterials.2014.05.014. View

Heo C, Yoo J, Lee S, Jo A, Jung S, Yoo H . The control of neural cell-to-cell interactions through non-contact electrical field stimulation using graphene electrodes. Biomaterials. 2010; 32(1):19-27. DOI: 10.1016/j.biomaterials.2010.08.095. View

Sasidharan A, Panchakarla L, Chandran P, Menon D, Nair S, Rao C . Differential nano-bio interactions and toxicity effects of pristine versus functionalized graphene. Nanoscale. 2011; 3(6):2461-4. DOI: 10.1039/c1nr10172b. View

Novoselov K, Jiang Z, Zhang Y, Morozov S, Stormer H, Zeitler U . Room-temperature quantum Hall effect in graphene. Science. 2007; 315(5817):1379. DOI: 10.1126/science.1137201. View

Cho Y, Ben Borgens R . Electrically controlled release of the nerve growth factor from a collagen-carbon nanotube composite for supporting neuronal growth. J Mater Chem B. 2020; 1(33):4166-4170. DOI: 10.1039/c3tb20505c. View

10.

Zhu Z, Jiang H, Susi T, Nasibulin A, Kauppinen E . The use of NH3 to promote the production of large-diameter single-walled carbon nanotubes with a narrow (n,m) distribution. J Am Chem Soc. 2011; 133(5):1224-7. DOI: 10.1021/ja1087634. View

11.

Ahadian S, Yamada S, Ramon-Azcon J, Estili M, Liang X, Nakajima K . Hybrid hydrogel-aligned carbon nanotube scaffolds to enhance cardiac differentiation of embryoid bodies. Acta Biomater. 2015; 31:134-143. DOI: 10.1016/j.actbio.2015.11.047. View

12.

Rangarajan S, Madden L, Bursac N . Use of flow, electrical, and mechanical stimulation to promote engineering of striated muscles. Ann Biomed Eng. 2013; 42(7):1391-405. PMC: 4069203. DOI: 10.1007/s10439-013-0966-4. View

13.

Ahadian S, Davenport Huyer L, Estili M, Yee B, Smith N, Xu Z . Moldable elastomeric polyester-carbon nanotube scaffolds for cardiac tissue engineering. Acta Biomater. 2016; 52:81-91. DOI: 10.1016/j.actbio.2016.12.009. View

14.

Liu Y, Zhao Y, Sun B, Chen C . Understanding the toxicity of carbon nanotubes. Acc Chem Res. 2012; 46(3):702-13. DOI: 10.1021/ar300028m. View

15.

BASSETT C, PAWLUK R, Becker R . EFFECTS OF ELECTRIC CURRENTS ON BONE IN VIVO. Nature. 1964; 204:652-4. DOI: 10.1038/204652a0. View

16.

Kam N, Dai H . Carbon nanotubes as intracellular protein transporters: generality and biological functionality. J Am Chem Soc. 2005; 127(16):6021-6. DOI: 10.1021/ja050062v. View

17.

Deng B, Liu Z, Peng H . Toward Mass Production of CVD Graphene Films. Adv Mater. 2018; 31(9):e1800996. DOI: 10.1002/adma.201800996. View

18.

Namgung S, Baik K, Park J, Hong S . Controlling the growth and differentiation of human mesenchymal stem cells by the arrangement of individual carbon nanotubes. ACS Nano. 2011; 5(9):7383-90. DOI: 10.1021/nn2023057. View

19.

Yu H, Zhang B, Bulin C, Li R, Xing R . High-efficient Synthesis of Graphene Oxide Based on Improved Hummers Method. Sci Rep. 2016; 6:36143. PMC: 5093679. DOI: 10.1038/srep36143. View

20.

Park H, Bhalla R, Saigal R, Radisic M, Watson N, Langer R . Effects of electrical stimulation in C2C12 muscle constructs. J Tissue Eng Regen Med. 2008; 2(5):279-87. PMC: 2782921. DOI: 10.1002/term.93. View