Preserving Inhibition with a Disinhibitory Microcircuit in the Retina

Overview

Journal Elife

Specialty Biology

Date 2020 Dec 3

PMID 33269700

Citations 9

Authors

Qiang Chen

Robert G Smith

Xiaolin Huang

Wei Wei

Affiliations

Soon will be listed here.

Abstract

Previously, we found that in the mammalian retina, inhibitory inputs onto starburst amacrine cells (SACs) are required for robust direction selectivity of On-Off direction-selective ganglion cells (On-Off DSGCs) against noisy backgrounds (Chen et al., 2016). However, the source of the inhibitory inputs to SACs and how this inhibition confers noise resilience of DSGCs are unknown. Here, we show that when visual noise is present in the background, the motion-evoked inhibition to an On-Off DSGC is preserved by a disinhibitory motif consisting of a serially connected network of neighboring SACs presynaptic to the DSGC. This preservation of inhibition by a disinhibitory motif arises from the interaction between visually evoked network dynamics and short-term synaptic plasticity at the SAC-DSGC synapse. Although the disinhibitory microcircuit is well studied for its disinhibitory function in brain circuits, our results highlight the algorithmic flexibility of this motif beyond disinhibition due to the mutual influence between network and synaptic plasticity mechanisms.

Citing Articles

Compartmentalized pooling generates orientation selectivity in wide-field amacrine cells.

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Short-term plasticity and context-dependent circuit function: Insights from retinal circuitry.

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Dendritic mGluR2 and perisomatic Kv3 signaling regulate dendritic computation of mouse starburst amacrine cells.

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Disinhibition Is an Essential Network Motif Coordinated by GABA Levels and GABA B Receptors.

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Two mechanisms for direction selectivity in a model of the primate starburst amacrine cell.

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