Th17 Functions As an Osteoclastogenic Helper T Cell Subset That Links T Cell Activation and Bone Destruction

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 2006 Nov 8

PMID 17088434

Citations 645

Authors

Kojiro Sato

Ayako Suematsu

Kazuo Okamoto

Akira Yamaguchi

Yasuyuki Morishita

Yuho Kadono

Sakae Tanaka

Tatsuhiko Kodama

Shizuo Akira

Yoichiro Iwakura

Daniel J Cua

Hiroshi Takayanagi

Affiliations

Soon will be listed here.

Abstract

In autoimmune arthritis, traditionally classified as a T helper (Th) type 1 disease, the activation of T cells results in bone destruction mediated by osteoclasts, but how T cells enhance osteoclastogenesis despite the anti-osteoclastogenic effect of interferon (IFN)-gamma remains to be elucidated. Here, we examine the effect of various Th cell subsets on osteoclastogenesis and identify Th17, a specialized inflammatory subset, as an osteoclastogenic Th cell subset that links T cell activation and bone resorption. The interleukin (IL)-23-IL-17 axis, rather than the IL-12-IFN-gamma axis, is critical not only for the onset phase, but also for the bone destruction phase of autoimmune arthritis. Thus, Th17 is a powerful therapeutic target for the bone destruction associated with T cell activation.

Citing Articles

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