A Systematic Comprehensive Longitudinal Evaluation of Dietary Factors Associated with Acute Myocardial Infarction and Fatal Coronary Heart Disease

Overview

Journal Nat Commun

Specialty Biology

Date 2020 Nov 28

PMID 33247093

Citations 20

Authors

Soodabeh Milanlouei

Giulia Menichetti

Yanping Li

Joseph Loscalzo

Walter C Willett

Albert-Laszlo Barabasi

Affiliations

Soon will be listed here.

Abstract

Environmental factors, and in particular diet, are known to play a key role in the development of Coronary Heart Disease. Many of these factors were unveiled by detailed nutritional epidemiology studies, focusing on the role of a single nutrient or food at a time. Here, we apply an Environment-Wide Association Study approach to Nurses' Health Study data to explore comprehensively and agnostically the association of 257 nutrients and 117 foods with coronary heart disease risk (acute myocardial infarction and fatal coronary heart disease). After accounting for multiple testing, we identify 16 food items and 37 nutrients that show statistically significant association - while adjusting for potential confounding and control variables such as physical activity, smoking, calorie intake, and medication use - among which 38 associations were validated in Nurses' Health Study II. Our implementation of Environment-Wide Association Study successfully reproduces prior knowledge of diet-coronary heart disease associations in the epidemiological literature, and helps us detect new associations that were only marginally studied, opening potential avenues for further extensive experimental validation. We also show that Environment-Wide Association Study allows us to identify a bipartite food-nutrient network, highlighting which foods drive the associations of specific nutrients with coronary heart disease risk.

Citing Articles

The Gut-Heart Axis: Molecular Perspectives and Implications for Myocardial Infarction.

Rivera K, Gonzalez L, Bravo L, Manjarres L, Andia M Int J Mol Sci. 2024; 25(22).

PMID: 39596530 PMC: 11595032. DOI: 10.3390/ijms252212465.

An Online Multimodal Food Data Exploration Platform for Specific Population Health: Development Study.

Yang L, Guo Z, Xu X, Kang H, Lai J, Li J JMIR Form Res. 2024; 8:e55088.

PMID: 39547662 PMC: 11607570. DOI: 10.2196/55088.

Decoding the Foodome: Molecular Networks Connecting Diet and Health.

Menichetti G, Barabasi A, Loscalzo J Annu Rev Nutr. 2024; 44(1):257-288.

PMID: 39207880 PMC: 11610447. DOI: 10.1146/annurev-nutr-062322-030557.

GroceryDB: Prevalence of Processed Food in Grocery Stores.

Ravandi B, Ispirova G, Sebek M, Mehler P, Barabasi A, Menichetti G medRxiv. 2024; .

PMID: 38883708 PMC: 11177926. DOI: 10.1101/2022.04.23.22274217.

Nursing Interventions and Care Strategies for Patients with Coronary Heart Disease: A Comprehensive Review.

Shan Y, Chen J, Zhou S, Wen G Galen Med J. 2024; 12:e2994.

PMID: 38774841 PMC: 11108677. DOI: 10.31661/gmj.v12i0.2994.

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