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Coronapp: A Web Application to Annotate and Monitor SARS-CoV-2 Mutations

Overview
Journal J Med Virol
Specialty Microbiology
Date 2020 Nov 18
PMID 33205830
Citations 53
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Abstract

The avalanche of genomic data generated from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus requires the development of tools to detect and monitor its mutations across the world. Here, we present a webtool, coronapp, dedicated to easily processing user-provided SARS-CoV-2 genomic sequences and visualizing the current worldwide status of SARS-CoV-2 mutations. The webtool allows users to highlight mutations and categorize them by frequency, country, genomic location and effect on protein sequences, and to monitor their presence in the population over time. The tool is available at http://giorgilab.unibo.it/coronannotator/ for the annotation of user-provided sequences. The full code is freely shared at https://github.com/federicogiorgi/giorgilab/tree/master/coronannotator.

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References
1.
Mercatelli D, Giorgi F . Geographic and Genomic Distribution of SARS-CoV-2 Mutations. Front Microbiol. 2020; 11:1800. PMC: 7387429. DOI: 10.3389/fmicb.2020.01800. View

2.
Ceraolo C, Giorgi F . Genomic variance of the 2019-nCoV coronavirus. J Med Virol. 2020; 92(5):522-528. PMC: 7166773. DOI: 10.1002/jmv.25700. View

3.
Guan W, Ni Z, Hu Y, Liang W, Ou C, He J . Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020; 382(18):1708-1720. PMC: 7092819. DOI: 10.1056/NEJMoa2002032. View

4.
Isabel S, Grana-Miraglia L, Gutierrez J, Bundalovic-Torma C, Groves H, Isabel M . Evolutionary and structural analyses of SARS-CoV-2 D614G spike protein mutation now documented worldwide. Sci Rep. 2020; 10(1):14031. PMC: 7441380. DOI: 10.1038/s41598-020-70827-z. View

5.
Zhang H, Penninger J, Li Y, Zhong N, Slutsky A . Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target. Intensive Care Med. 2020; 46(4):586-590. PMC: 7079879. DOI: 10.1007/s00134-020-05985-9. View