CORO7 Functions As a Scaffold Protein for the Core Kinase Complex Assembly of the Hippo Pathway

Overview

Journal J Biol Chem

Specialty Biochemistry

Date 2020 Nov 9

PMID 33162394

Citations 4

Authors

Jina Park

Kyoungho Jun

Yujin Choi

Eunju Yoon

Wonho Kim

Yoon-Gu Jang

Jongkyeong Chung

Affiliations

Soon will be listed here.

Abstract

The Hippo pathway controls organ size and tissue homeostasis through the regulation of cell proliferation and apoptosis. However, the exact molecular mechanisms underpinning Hippo pathway regulation are not fully understood. Here, we identify a new component of the Hippo pathway: coronin 7 (CORO7), a coronin protein family member that is involved in organization of the actin cytoskeleton. pod1, the Drosophila ortholog of CORO7, genetically interacts with key Hippo pathway genes in Drosophila. In mammalian cells, CORO7 is required for the activation of the Hippo pathway in response to cell-cell contact, serum deprivation, and cytoskeleton damage. CORO7 forms a complex with the core components of the pathway and functions as a scaffold for the Hippo core kinase complex. Collectively, these results demonstrate that CORO7 is a key scaffold controlling the Hippo pathway via modulating protein-protein interactions.

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