Prior Exposure to Subimmunogenic Amounts of Some Bacterial Lipopolysaccharides Induces Specific Immunological Unresponsiveness

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1987 Dec 1

PMID 3316031

Citations 6

Authors

K L Elkins

P W STASHAK

P J Baker

Affiliations

Soon will be listed here.

Abstract

Pretreatment (priming) of BALB/c mice with a low (subimmunogenic) dose of Escherichia coli O113 lipopolysaccharide (LPS) generates immunological memory 7 to 30 days later; the direct (immunoglobulin M) plaque-forming cell (PFC) responses produced after subsequent immunization with an optimal dose are 4 to 20 times greater than those of unprimed mice. By contrast, priming with a low dose of E. coli O55 LPS, followed by immunization with an optimally immunogenic dose 2 to 30 days later, resulted in a significantly reduced antibody response. Similar results were obtained with Serratia marcescens LPS. Dose-response studies indicated that such unresponsiveness is antigen specific and could be induced with subimmunogenic amounts of LPS. Priming reduced the magnitude of the PFC response to all immunizing doses of LPS tested. Unresponsiveness is not due to (i) an alteration in the time course of the PFC response or to (ii) a change in the isotype of the anti-LPS antibody produced after priming and immunization.

Citing Articles

Molecular structures that influence the immunomodulatory properties of the lipid A and inner core region oligosaccharides of bacterial lipopolysaccharides.

Baker P, HRABA T, Taylor C, STASHAK P, Fauntleroy M, Zahringer U Infect Immun. 1994; 62(6):2257-69.

PMID: 8188347 PMC: 186506. DOI: 10.1128/iai.62.6.2257-2269.1994.

Specific immunological unresponsiveness to bacterial lipopolysaccharides develops in a cyclic manner.

Elkins K, STASHAK P, Baker P Infect Immun. 1989; 57(7):2253-5.

PMID: 2471694 PMC: 313869. DOI: 10.1128/iai.57.7.2253-2255.1989.

T-cell modulation of the antibody response to bacterial polysaccharide antigens.

Taylor C, Bright R Infect Immun. 1989; 57(1):180-5.

PMID: 2462536 PMC: 313065. DOI: 10.1128/iai.57.1.180-185.1989.

Protective immunization against experimental Bacteroides (Porphyromonas) gingivalis infection.

Chen P, Davern L, Schifferle R, Zambon J Infect Immun. 1990; 58(10):3394-400.

PMID: 2401568 PMC: 313666. DOI: 10.1128/iai.58.10.3394-3400.1990.

Regulation of magnitude of antibody response to bacterial polysaccharide antigens by thymus-derived lymphocytes.

Baker P Infect Immun. 1990; 58(11):3465-8.

PMID: 2228218 PMC: 313684. DOI: 10.1128/iai.58.11.3465-3468.1990.

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