Specific Immunological Unresponsiveness to Bacterial Lipopolysaccharides Develops in a Cyclic Manner

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1989 Jul 1

PMID 2471694

Citations 1

Authors

K L Elkins

P W STASHAK

P J Baker

Affiliations

Soon will be listed here.

Abstract

Prior exposure (priming) of BALB/cByJ mice to a low dose of lipopolysaccharide derived from Escherichia coli 055 or Serratia marcescens, followed by immunization with an optimally immunogenic dose of the same lipopolysaccharide 2 to 30 days later, results in the expression of substantially reduced antibody responses. Such unresponsiveness, which is antigen specific, occurs in a cyclic manner with time after priming.

Citing Articles

Toxicity and immunogenicity of Neisseria meningitidis lipopolysaccharide incorporated into liposomes.

Petrov A, SEMENOV B, Vartanyan Y, Zakirov M, Torchilin V, Trubetskoy V Infect Immun. 1992; 60(9):3897-903.

PMID: 1500196 PMC: 257405. DOI: 10.1128/iai.60.9.3897-3903.1992.

References

Britton S, Wepsic T, Moller G . Persistence of immunogenicity of two complex antigens retained in vivo. Immunology. 1968; 14(4):491-501. PMC: 1409385. View

Elkins K, STASHAK P, Baker P . Mechanisms of specific immunological unresponsiveness to bacterial lipopolysaccharides. Infect Immun. 1987; 55(12):3093-102. PMC: 260033. DOI: 10.1128/iai.55.12.3093-3102.1987. View

Baker P, STASHAK P . Quantitative and qualitative studies on the primary antibody response to pneumococcal polysaccharides at ehe cellular level. J Immunol. 1969; 103(6):1342-8. View

Gottlieb C . Application of transformations to normalize the distribution of plaque-forming cells. J Immunol. 1974; 113(1):51-7. View

Von Eschen K, Rudbach J . Immunological responses of mice to native protoplasmic polysaccharide and lipopolysaccharide: functional separation of the two signals required to stimulate a secondary antibody response. J Exp Med. 1974; 140(6):1604-14. PMC: 2139752. DOI: 10.1084/jem.140.6.1604. View

Weigle W . Cyclical production of antibody as a regulatory mechanism in the immune response. Adv Immunol. 1975; 21:87-111. DOI: 10.1016/s0065-2776(08)60219-9. View

Rudbach J, REED N . Immunological responses of mice to lipopolysaccharide: lack of secondary responsiveness by C3H/HeJ mice. Infect Immun. 1977; 16(2):513-7. PMC: 420983. DOI: 10.1128/iai.16.2.513-517.1977. View

Rosenstreich D, Vogel S, Jacques A, Wahl L, SCHER I, Mergenhagen S . Differential endotoxin sensitivity of lymphocytes and macrophages from mice with an X-linked defect in B cell maturation. J Immunol. 1978; 121(2):685-90. View

Von Eschen K, Rudbach J . Dissociation of the anti-hapten and anti-carrier responses of mice injected with dinitrophenylated lipopolysaccharide. Infect Immun. 1981; 31(1):327-33. PMC: 351786. DOI: 10.1128/iai.31.1.327-333.1981. View

10.

Baker P, Amsbaugh D, STASHAK P, Caldes G, PRESCOTT B . Regulation of the antibody response to pneumococcal polysaccharide by thymus-derived cells. Rev Infect Dis. 1981; 3(2):332-41. DOI: 10.1093/clinids/3.2.332. View

11.

Taylor C, Amsbaugh D, STASHAK P, Caldes G, PRESCOTT B, Baker P . Cell surface antigens and other characteristics of T cells regulating the antibody response to type III pneumococcal polysaccharide. J Immunol. 1983; 130(1):19-23. View

12.

Hiernaux J, Jones J, Rudbach J, Rollwagen F, Baker P . Antibody response of immunodeficient (xid) CBA/N mice to Escherichia coli 0113 lipopolysaccharide, a thymus-independent antigen. J Exp Med. 1983; 157(4):1197-207. PMC: 2186980. DOI: 10.1084/jem.157.4.1197. View

13.

STASHAK P, Taylor C, Caldes G, PRESCOTT B, Baker P . Cyclic expression of low-dose paralysis. Cell Immunol. 1983; 77(1):143-9. DOI: 10.1016/0008-8749(83)90014-x. View

14.

Baker P, Hiernaux J, STASHAK P, Rudbach J . Cyclic development of immunological memory to bacterial lipopolysaccharide. Infect Immun. 1985; 48(1):1-6. PMC: 261904. DOI: 10.1128/iai.48.1.1-6.1985. View

15.

Elkins K, STASHAK P, Baker P . Prior exposure to subimmunogenic amounts of some bacterial lipopolysaccharides induces specific immunological unresponsiveness. Infect Immun. 1987; 55(12):3085-92. PMC: 260032. DOI: 10.1128/iai.55.12.3085-3092.1987. View

16.

Baker P, STASHAK P, PRESCOTT B . Use of erythrocytes sensitized with purified pneumococcal polysaccharides for the assay of antibody and antibody-producing cells. Appl Microbiol. 1969; 17(3):422-6. PMC: 377705. DOI: 10.1128/am.17.3.422-426.1969. View