Direct Evidence for the Involvement of T Suppressor Cells in the Expression of Low-dose Paralysis to Type III Pneumococcal Polysaccharide

Overview

Journal J Immunol

Specialty Allergy & Immunology

Date 1982 Mar 1

PMID 6173416

Citations 29

Authors

P J Baker

D F Amsbaugh

P W STASHAK

G Caldes

B PRESCOTT

Affiliations

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Abstract

Prior treatment (priming) with a subimmunogenic dose of type III pneumococcal polysaccharide results in the development of an antigen-specific state of unresponsiveness termed low-dose paralysis. Such unresponsiveness can be transferred by spleen cells obtained from mice within 5 to 24 hr after priming; the suppressive activity of transferred cells is abolished by treatment with monoclonal anti-Thy-1.2 antibody and complement. These findings show clearly that low-dose paralysis is mediated by T suppressor cells.

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