The Role of Neutrophils in the Pathophysiology of Asthma in Humans and Horses

Overview

Journal Inflammation

Specialties Allergy & Immunology
Pathology

Date 2020 Nov 5

PMID 33150539

Citations 9

Authors

Kaori Uchiumi Davis

M Katie Sheats

Affiliations

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Abstract

Asthma is a common and debilitating chronic airway disease that affects people and horses of all ages worldwide. While asthma in humans most commonly involves an excessive type 2 immune response and eosinophilic inflammation, neutrophils have also been recognized as key players in the pathophysiology of asthma, including in the severe asthma phenotype where neutrophilic inflammation predominates. Severe equine asthma syndrome (sEAS) features prominent neutrophilic inflammation and has been increasingly used as a naturally occurring animal model for the study of human neutrophilic asthma. This comparative review examines the recent literature in order to explore the role of neutrophil inflammatory functions in the pathophysiology and immunology of asthma in humans and horses.

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