Asthma: The Use of Animal Models and Their Translational Utility

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2023 Apr 13

PMID 37048164

Authors

Jane Seymour Woodrow

M Katie Sheats

Bethanie Cooper

Rosemary Bayless

Affiliations

Soon will be listed here.

Abstract

Asthma is characterized by chronic lower airway inflammation that results in airway remodeling, which can lead to a permanent decrease in lung function. The pathophysiology driving the development of asthma is complex and heterogenous. Animal models have been and continue to be essential for the discovery of molecular pathways driving the pathophysiology of asthma and novel therapeutic approaches. Animal models of asthma may be induced or naturally occurring. Species used to study asthma include mouse, rat, guinea pig, cat, dog, sheep, horse, and nonhuman primate. Some of the aspects to consider when evaluating any of these asthma models are cost, labor, reagent availability, regulatory burden, relevance to natural disease in humans, type of lower airway inflammation, biological samples available for testing, and ultimately whether the model can answer the research question(s). This review aims to discuss the animal models most available for asthma investigation, with an emphasis on describing the inciting antigen/allergen, inflammatory response induced, and its translation to human asthma.

Citing Articles

Respiratory extracellular vesicle isolation optimization through proteomic profiling of equine samples and identification of candidates for cell-of-origin studies.

Hickman E, Carberry V, Carberry C, Cooper B, Mordant A, Mills A PLoS One. 2025; 20(1):e0315743.

PMID: 39854355 PMC: 11760557. DOI: 10.1371/journal.pone.0315743.

The role of DC subgroups in the pathogenesis of asthma.

Xu J, Cao S, Xu Y, Chen H, Nian S, Li L Front Immunol. 2024; 15:1481989.

PMID: 39530090 PMC: 11550972. DOI: 10.3389/fimmu.2024.1481989.

Immunologic aspects of asthma: from molecular mechanisms to disease pathophysiology and clinical translation.

Xie C, Yang J, Gul A, Li Y, Zhang R, Yalikun M Front Immunol. 2024; 15:1478624.

PMID: 39439788 PMC: 11494396. DOI: 10.3389/fimmu.2024.1478624.

The Impact of High-Fructose Diet and Co-Sensitization to House Dust Mites and Ragweed Pollen on the Modulation of Airway Reactivity and Serum Biomarkers in Rats.

Zimbru R, Zimbru E, Ordodi V, Bojin F, Crisnic D, Grijincu M Int J Mol Sci. 2024; 25(16).

PMID: 39201554 PMC: 11354849. DOI: 10.3390/ijms25168868.

Adjuvant-independent airway sensitization and infection mouse models leading to allergic asthma.

Radhouani M, Starkl P Front Allergy. 2024; 5:1423938.

PMID: 39157265 PMC: 11327155. DOI: 10.3389/falgy.2024.1423938.

References

Seys S, Lokwani R, Simpson J, Bullens D . New insights in neutrophilic asthma. Curr Opin Pulm Med. 2018; 25(1):113-120. DOI: 10.1097/MCP.0000000000000543. View

Abraham W, Burch R, FARMER S, Sielczak M, Ahmed A, Cortes A . A bradykinin antagonist modifies allergen-induced mediator release and late bronchial responses in sheep. Am Rev Respir Dis. 1991; 143(4 Pt 1):787-96. DOI: 10.1164/ajrccm/143.4_Pt_1.787. View

Davis K, Sheats M . The Role of Neutrophils in the Pathophysiology of Asthma in Humans and Horses. Inflammation. 2020; 44(2):450-465. DOI: 10.1007/s10753-020-01362-2. View

Renzi P, Olivenstein R, Martin J . Inflammatory cell populations in the airways and parenchyma after antigen challenge in the rat. Am Rev Respir Dis. 1993; 147(4):967-74. DOI: 10.1164/ajrccm/147.4.967. View

Moise N, Wiedenkeller D, Yeager A, Blue J, Scarlett J . Clinical, radiographic, and bronchial cytologic features of cats with bronchial disease: 65 cases (1980-1986). J Am Vet Med Assoc. 1989; 194(10):1467-73. View

Abraham W, Delehunt J, Yerger L, Marchette B . Characterization of a late phase pulmonary response after antigen challenge in allergic sheep. Am Rev Respir Dis. 1983; 128(5):839-44. DOI: 10.1164/arrd.1983.128.5.839. View

Dos Santos Rocha A, Sudy R, Petak F, Habre W . Physiologically variable ventilation in a rabbit model of asthma exacerbation. Br J Anaesth. 2020; 125(6):1107-1116. DOI: 10.1016/j.bja.2020.08.059. View

Yasuda Y, Nagano T, Kobayashi K, Nishimura Y . Group 2 Innate Lymphoid Cells and the House Dust Mite-Induced Asthma Mouse Model. Cells. 2020; 9(5). PMC: 7290734. DOI: 10.3390/cells9051178. View

Boswell-Smith V, Spina D, Oxford A, Comer M, Seeds E, Page C . The pharmacology of two novel long-acting phosphodiesterase 3/4 inhibitors, RPL554 [9,10-dimethoxy-2(2,4,6-trimethylphenylimino)-3-(n-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one] and RPL565.... J Pharmacol Exp Ther. 2006; 318(2):840-8. DOI: 10.1124/jpet.105.099192. View

10.

Soler M, Sielczak M, Abraham W . A PAF antagonist blocks antigen-induced airway hyperresponsiveness and inflammation in sheep. J Appl Physiol (1985). 1989; 67(1):406-13. DOI: 10.1152/jappl.1989.67.1.406. View

11.

Leigh R, Ellis R, Wattie J, Southam D, De Hoogh M, Gauldie J . Dysfunction and remodeling of the mouse airway persist after resolution of acute allergen-induced airway inflammation. Am J Respir Cell Mol Biol. 2002; 27(5):526-35. DOI: 10.1165/rcmb.2002-0048OC. View

12.

Choi I, Sun-Kim , Kim Y, Ko H, Im S, Kim J . TNF-alpha induces the late-phase airway hyperresponsiveness and airway inflammation through cytosolic phospholipase A(2) activation. J Allergy Clin Immunol. 2005; 116(3):537-43. DOI: 10.1016/j.jaci.2005.05.034. View

13.

McDowell P, Heaney L . Different endotypes and phenotypes drive the heterogeneity in severe asthma. Allergy. 2019; 75(2):302-310. DOI: 10.1111/all.13966. View

14.

Henderson Jr W, Tang L, Chu S, Tsao S, Chiang G, Jones F . A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model. Am J Respir Crit Care Med. 2002; 165(1):108-16. DOI: 10.1164/ajrccm.165.1.2105051. View

15.

Krell R, Kusner E, Aharony D, Giles R . Biochemical and pharmacological characterization of ICI 198,615: a peptide leukotriene receptor antagonist. Eur J Pharmacol. 1989; 159(1):73-81. DOI: 10.1016/0014-2999(89)90045-9. View

16.

Yasue M, Nakamura S, Yokota T, Okudaira H, Okumura Y . Experimental monkey model sensitized with mite antigen. Int Arch Allergy Immunol. 1998; 115(4):303-11. DOI: 10.1159/000069461. View

17.

Park J, Kim Y, Lee S, Cho S, Min K, Kim Y . Repeated exposure to low levels of sulfur dioxide (SO2) enhances the development of ovalbumin-induced asthmatic reactions in guinea pigs. Ann Allergy Asthma Immunol. 2001; 86(1):62-7. DOI: 10.1016/S1081-1206(10)62358-7. View

18.

Krell R, Chakrin L, Christian P, Giannone E, McCoy J, Osborn R . Canine airway responses to acetylcholine, prostaglandin F2alpha, histamine, and serotonin after chronic antigen exposure. J Allergy Clin Immunol. 1976; 58(6):664-75. DOI: 10.1016/0091-6749(76)90178-0. View

19.

Ishii A, Nakagawa T, Nambu F, Motoishi M, Miyamoto T . Inhibition of endogenous leukotriene-mediated lung anaphylaxis in guinea pigs by a novel receptor antagonist ONO-1078. Int Arch Allergy Appl Immunol. 1990; 92(4):404-7. DOI: 10.1159/000235172. View

20.

Duez C, Tsicopoulos A, Janin A, Tillie-Leblond I, Thyphronitis G, Marquillies P . An in vivo model of allergic inflammation: pulmonary human cell infiltrate in allergen-challenged allergic Hu-SCID mice. Eur J Immunol. 1996; 26(5):1088-93. DOI: 10.1002/eji.1830260520. View