Resistance in Vancomycin-Resistant Enterococci

Overview

Journal Infect Dis Clin North Am

Specialty Infectious Diseases

Date 2020 Nov 2

PMID 33131572

Citations 49

Authors

William R Miller

Barbara E Murray

Louis B Rice

Cesar A Arias

Affiliations

Soon will be listed here.

Abstract

Serious infections owing to vancomycin-resistant enterococci have historically proven to be difficult clinical cases, requiring combination therapy and management of treatment-related toxicity. Despite the introduction of new antibiotics with activity against vancomycin-resistant enterococci to the therapeutic armamentarium, significant challenges remain. An understanding of the factors driving the emergence of resistance in vancomycin-resistant enterococci, the dynamics of gastrointestinal colonization and microbiota-mediated colonization resistance, and the mechanisms of resistance to the currently available therapeutics will permit clinicians to be better prepared to tackle these challenging hospital-associated pathogens.

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