Exosomes: Novel Players of Therapy Resistance in Neuroblastoma

Overview

Journal Adv Exp Med Biol

Specialties Biology
General Medicine

Date 2020 Oct 29

PMID 33119866

Citations 8

Authors

Heather Richard

Arya Pokhrel

Srinivas Chava

Anup Pathania

Santharam S Katta

Kishore B Challagundla

Affiliations

Soon will be listed here.

Abstract

Neuroblastoma is a solid tumor (a lump or mass), often found in the small glands on top of the kidneys, and most commonly affects infants and young children. Among neuroblastomas, high-risk neuroblastomas are very aggressive and resistant to most kinds of intensive treatment. Immunotherapy, which uses the immune system to fight against cancer, has shown great promise in treating many types of cancer. However, high-risk neuroblastoma is often resistant to this approach as well. Recent studies revealed that small vesicles known as exosomes, which are envelopes, could deliver a cargo of small RNA molecules and provide communication between neuroblastoma cells and the surrounding cells and trigger metastasis and resistance to immunotherapy. In this chapter, we describe the role of exosomes and small RNA molecules in the metastasis and regression of neuroblastoma and the potential therapeutic approaches to combat this menace.

Citing Articles

Immunomodulatory properties of extracellular vesicles isolated from bone marrow of patients with neuroblastoma: role of PD-L1 and HLA-G.

Marimpietri D, Corrias M, Tripodi G, Gramignoli R, Airoldi I, Morandi F Front Immunol. 2024; 15:1469771.

PMID: 39512342 PMC: 11540764. DOI: 10.3389/fimmu.2024.1469771.

Advances in liquid biopsy in neuroblastoma.

Zhuo Z, Lin L, Miao L, Li M, He J Fundam Res. 2024; 2(6):903-917.

PMID: 38933377 PMC: 11197818. DOI: 10.1016/j.fmre.2022.08.005.

SAP30, an oncogenic driver of progression, poor survival, and drug resistance in neuroblastoma.

Prathipati P, Pathania A, Chaturvedi N, Gupta S, Byrareddy S, Coulter D Mol Ther Nucleic Acids. 2024; 35(2):101543.

PMID: 38817681 PMC: 11137595. DOI: 10.1016/j.omtn.2022.03.014.

Safety and efficacy of dinutuximab in the treatment of neuroblastoma: A review.

Mohd A, Mohd O, Alabdallat Y, Al Dwairy S, Ghannam R, Hanaqtah B J Res Med Sci. 2023; 28:71.

PMID: 38116487 PMC: 10729685. DOI: 10.4103/jrms.jrms_727_22.

A novel cuproptosis-related gene signature predicting overall survival in pediatric neuroblastoma patients.

Yang H, Yang J, Bian H, Wang X Front Pediatr. 2022; 10:1049858.

PMID: 36568423 PMC: 9768227. DOI: 10.3389/fped.2022.1049858.

References

Baker D, Schmidt M, Cohn S, Maris J, London W, Buxton A . Outcome after reduced chemotherapy for intermediate-risk neuroblastoma. N Engl J Med. 2010; 363(14):1313-23. PMC: 2993160. DOI: 10.1056/NEJMoa1001527. View

Maia J, Caja S, Moraes M, Couto N, Costa-Silva B . Exosome-Based Cell-Cell Communication in the Tumor Microenvironment. Front Cell Dev Biol. 2018; 6:18. PMC: 5826063. DOI: 10.3389/fcell.2018.00018. View

Pinto N, Applebaum M, Volchenboum S, Matthay K, London W, Ambros P . Advances in Risk Classification and Treatment Strategies for Neuroblastoma. J Clin Oncol. 2015; 33(27):3008-17. PMC: 4567703. DOI: 10.1200/JCO.2014.59.4648. View

Seeger R . Immunology and immunotherapy of neuroblastoma. Semin Cancer Biol. 2011; 21(4):229-37. PMC: 3658311. DOI: 10.1016/j.semcancer.2011.09.012. View

London W, Castleberry R, Matthay K, Look A, Seeger R, Shimada H . Evidence for an age cutoff greater than 365 days for neuroblastoma risk group stratification in the Children's Oncology Group. J Clin Oncol. 2005; 23(27):6459-65. DOI: 10.1200/JCO.2005.05.571. View

Speleman F, Park J, Henderson T . Neuroblastoma: A Tough Nut to Crack. Am Soc Clin Oncol Educ Book. 2016; 35:e548-57. DOI: 10.1200/EDBK_159169. View

Aslam M, Baveja R, Liang O, Fernandez-Gonzalez A, Lee C, Mitsialis S . Bone marrow stromal cells attenuate lung injury in a murine model of neonatal chronic lung disease. Am J Respir Crit Care Med. 2009; 180(11):1122-30. PMC: 2784417. DOI: 10.1164/rccm.200902-0242OC. View

Zhang Y, Chopp M, Meng Y, Katakowski M, Xin H, Mahmood A . Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury. J Neurosurg. 2015; 122(4):856-67. PMC: 4382456. DOI: 10.3171/2014.11.JNS14770. View

Maas S, Breakefield X, Weaver A . Extracellular Vesicles: Unique Intercellular Delivery Vehicles. Trends Cell Biol. 2016; 27(3):172-188. PMC: 5318253. DOI: 10.1016/j.tcb.2016.11.003. View

10.

Zhang Y, Liu Y, Liu H, Tang W . Exosomes: biogenesis, biologic function and clinical potential. Cell Biosci. 2019; 9:19. PMC: 6377728. DOI: 10.1186/s13578-019-0282-2. View

11.

Chava S, Reynolds C, Pathania A, Gorantla S, Poluektova L, Coulter D . miR-15a-5p, miR-15b-5p, and miR-16-5p inhibit tumor progression by directly targeting MYCN in neuroblastoma. Mol Oncol. 2019; 14(1):180-196. PMC: 6944109. DOI: 10.1002/1878-0261.12588. View

12.

Huang M, Weiss W . Neuroblastoma and MYCN. Cold Spring Harb Perspect Med. 2013; 3(10):a014415. PMC: 3784814. DOI: 10.1101/cshperspect.a014415. View

13.

Challagundla K, Wise P, Neviani P, Chava H, Murtadha M, Xu T . Exosome-mediated transfer of microRNAs within the tumor microenvironment and neuroblastoma resistance to chemotherapy. J Natl Cancer Inst. 2015; 107(7). PMC: 4651042. DOI: 10.1093/jnci/djv135. View

14.

Birbrair A, Zhang T, Wang Z, Messi M, Olson J, Mintz A . Type-2 pericytes participate in normal and tumoral angiogenesis. Am J Physiol Cell Physiol. 2014; 307(1):C25-38. PMC: 4080181. DOI: 10.1152/ajpcell.00084.2014. View

15.

Cohn S, Pearson A, London W, Monclair T, Ambros P, Brodeur G . The International Neuroblastoma Risk Group (INRG) classification system: an INRG Task Force report. J Clin Oncol. 2008; 27(2):289-97. PMC: 2650388. DOI: 10.1200/JCO.2008.16.6785. View

16.

Szakacs G, Paterson J, Ludwig J, Booth-Genthe C, Gottesman M . Targeting multidrug resistance in cancer. Nat Rev Drug Discov. 2006; 5(3):219-34. DOI: 10.1038/nrd1984. View

17.

Lee C, Mitsialis S, Aslam M, Vitali S, Vergadi E, Konstantinou G . Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension. Circulation. 2012; 126(22):2601-11. PMC: 3979353. DOI: 10.1161/CIRCULATIONAHA.112.114173. View

18.

Daudigeos-Dubus E, Le Dret L, Rouffiac V, Bawa O, Leguerney I, Opolon P . Establishment and characterization of new orthotopic and metastatic neuroblastoma models. In Vivo. 2014; 28(4):425-34. View

19.

Ma J, Xu M, Yin M, Hong J, Chen H, Gao Y . Exosomal hsa-miR199a-3p Promotes Proliferation and Migration in Neuroblastoma. Front Oncol. 2019; 9:459. PMC: 6582313. DOI: 10.3389/fonc.2019.00459. View

20.

Lai R, Arslan F, Lee M, Sze N, Choo A, Chen T . Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury. Stem Cell Res. 2010; 4(3):214-22. DOI: 10.1016/j.scr.2009.12.003. View