Metabolic Defects in Splenic B Cell Compartments from Patients with Liver Cirrhosis

Overview

Journal Cell Death Dis

Specialties Cell Biology
General Medicine

Date 2020 Oct 25

PMID 33099582

Citations 3

Authors

Man Huang

Xiaoju Liu

Haocheng Ye

Xin Zhao

Juanjuan Zhao

Yang Liu

Xiaomeng He

Mengmeng Qu

Jing Pan

Baidong Hou

Yongqian Cheng

Zhenwen Liu

Zhiwei Li

Lei Liu

Jian Sun

Shuye Zhang

Zheng Zhang

Affiliations

Soon will be listed here.

Abstract

Liver cirrhosis is associated with defective vaccine responses and increased infections. Dysregulated B cell compartments in cirrhotic patients have been noticed but not well characterized, especially in the spleen. Here, we comprehensively investigated B cell perturbations from the spleens and peripheral blood of cirrhotic patients. We found that liver cirrhosis significantly depleted both switched and nonswitched splenic memory B cells, which was further confirmed histologically. Bulk RNA-seq revealed significant metabolic defects as the potential mechanism for the impaired splenic B cell functions. Functionally, the splenic memory B cells from cirrhotic patients showed strong metabolic defects and reduced proliferation compared with those from healthy controls. Thus, liver cirrhosis extensively disturbs the splenic and peripheral B cell compartments, which may contribute to defective humoral immunity during liver cirrhosis.

Citing Articles

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