A Novel Human B Cell Subpopulation Representing the Initial Germinal Center Population to Express AID

Overview

Journal Blood

Publisher Elsevier

Specialty Hematology

Date 2006 Nov 30

PMID 17132718

Citations 25

Authors

Grant R Kolar

Darshna Mehta

Rosana Pelayo

J Donald Capra

Affiliations

Soon will be listed here.

Abstract

We have identified a novel mature human B-cell subpopulation in the human tonsil that has characteristics of both naive B cells and germinal center B cells including the expression of activation-induced cytidine deaminase (AID), which is essential for the process of immunoglobulin somatic hypermutation and class-switch recombination. These cells are clearly somatically hypermutated, albeit modestly. Their phenotype (IgD(+)CD38(-)CD23(-)FSC(hi)CD71(+)) is unique and suggests they may be intermediate between both naive and germinal center cells. Morphologically they are also distinct from other B-cell subpopulations. The evidence presented suggests these cells may be the founder cells of the germinal center reaction (a pro-GC cell) and may be the normal counterpart of the mantle cell lymphoma cell.

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