Engineering a Model to Study Viral Infections: Bioprinting, Microfluidics, and Organoids to Defeat Coronavirus Disease 2019 (COVID-19)

Overview

Journal Int J Bioprint

Specialty Biomedical Engineering

Date 2020 Oct 22

PMID 33089000

Citations 20

Authors

Anastasia Shpichka

Polina Bikmulina

Maria Peshkova

Nastasia Kosheleva

Irina Zurina

Ensieh Zahmatkesh

Niloofar Khoshdel-Rad

Marina Lipina

Elena Golubeva

Denis Butnaru

Andrei Svistunov

Massoud Vosough

Peter Timashev

Affiliations

Soon will be listed here.

Abstract

While the number of studies related to severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) is constantly growing, it is essential to provide a framework of modeling viral infections. Therefore, this review aims to describe the background presented by earlier used models for viral studies and an approach to design an "ideal" tissue model for SARS-CoV-2 infection. Due to the previous successful achievements in antiviral research and tissue engineering, combining the emerging techniques such as bioprinting, microfluidics, and organoid formation are considered to be one of the best approaches to form tissue models. The fabrication of an integrated multi-tissue bioprinted platform tailored for SARS-CoV-2 infection can be a great breakthrough that can help defeat coronavirus disease in 2019.

Citing Articles

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