Urine Biomarker Assessment of Infant Adherence to Isoniazid Prophylaxis

Overview

Journal Pediatr Infect Dis J

Specialty Pediatrics

Date 2020 Oct 15

PMID 33055504

Citations 3

Authors

Sylvia M LaCourse

Daniel Leon

Nuttada Panpradist

Barbra A Richardson

Elizabeth Maleche-Obimbo

Jerphason Mecha

Daniel Matemo

Jaclyn N Escudero

John Kinuthia

Barry Lutz

Grace John-Stewart

Affiliations

Soon will be listed here.

Abstract

We assessed adherence in an infant tuberculosis prevention trial in Kenya with a urine isoniazid metabolite-detecting dipstick. Ninety-seven infants had 155 assays performed; 77 (49.7%) were found to be positive despite caregiver-reported adherence. Positive assays were associated with maternal secondary education, HIV suppression and no reported missed doses in past 3 days, suggesting caregiver education and self-medication use influenced infant adherence.

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