Reduced Fractional Anisotropy of the Genu of the Corpus Callosum As a Cerebrovascular Disease Marker and Predictor of Longitudinal Cognition in MCI

Overview

Journal Neurobiol Aging

Publisher Elsevier

Specialties Geriatrics
Neurology
Physiology

Date 2020 Oct 6

PMID 33022474

Citations 27

Authors

Sheelakumari Raghavan

Scott A Przybelski

Robert I Reid

Jonathan Graff-Radford

Timothy G Lesnick

Samantha M Zuk

David S Knopman

Mary M Machulda

Michelle M Mielke

Ronald C Petersen

Clifford R Jack Jr

Prashanthi Vemuri

Affiliations

Soon will be listed here.

Abstract

Our goal was to evaluate the utility of diffusion tensor imaging (DTI) for predicting future cognitive decline in mild cognitive impairment (MCI) in conjunction with Alzheimer's disease (AD) biomarkers (amyloid positron emission tomography and AD signature neurodegeneration) in 132 MCI individuals ≥60 year old with structural magnetic resonance imaging, DTI, amyloid positron emission tomography, and at least one clinical follow-up. We used mixed-effect models to evaluate the prognostic ability of fractional anisotropy of the genu of the corpus callosum (FA-Genu), as a cerebrovascular disease marker, for predicting cognitive decline along with AD biomarkers. We contrasted the value of white matter hyperintensities, a traditional cerebrovascular disease marker as well as FA in the hippocampal cingulum bundle with the FA-Genu models. FA-Genu significantly predicted cognitive decline even after accounting for AD biomarkers. WMH was not associated with cognitive decline in the model with both WMH and FA-Genu. DTI specifically FA-Genu provides unique complementary information to AD biomarkers and has significant utility for prediction of cognitive decline in MCI.

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