The Biomarker and Therapeutic Potential of Circular Rnas in Schizophrenia

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2020 Oct 6

PMID 33020462

Citations 3

Authors

Artem Nedoluzhko

Natalia Gruzdeva

Fedor Sharko

Sergey Rastorguev

Natalia Zakharova

Georgy Kostyuk

Vadim Ushakov

Affiliations

Soon will be listed here.

Abstract

Circular RNAs (circRNAs) are endogenous, single-stranded, most frequently non-coding RNA (ncRNA) molecules that play a significant role in gene expression regulation. Circular RNAs can affect microRNA functionality, interact with RNA-binding proteins (RBPs), translate proteins by themselves, and directly or indirectly modulate gene expression during different cellular processes. The affected expression of circRNAs, as well as their targets, can trigger a cascade of events in the genetic regulatory network causing pathological conditions. Recent studies have shown that altered circular RNA expression patterns could be used as biomarkers in psychiatric diseases, including schizophrenia (SZ); moreover, circular RNAs together with other cell molecules could provide new insight into mechanisms of this disorder. In this review, we focus on the role of circular RNAs in the pathogenesis of SZ and analyze their biomarker and therapeutic potential in this disorder.

Citing Articles

Circular RNAs: Diagnostic and Therapeutic Perspectives in CNS Diseases.

Bai Y, Yao H Curr Med Sci. 2023; 43(5):879-889.

PMID: 37815742 DOI: 10.1007/s11596-023-2784-8.

CircPrime: a web-based platform for design of specific circular RNA primers.

Sharko F, Rbbani G, Siriyappagouder P, Raeymaekers J, Galindo-Villegas J, Nedoluzhko A BMC Bioinformatics. 2023; 24(1):205.

PMID: 37208611 PMC: 10197314. DOI: 10.1186/s12859-023-05331-y.

Circular RNAs: Non-Canonical Observations on Non-Canonical RNAs.

Stringer B, Gantley L, Conn S Cells. 2023; 12(2).

PMID: 36672257 PMC: 9856604. DOI: 10.3390/cells12020323.

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