Schizophrenia

Overview

Journal Lancet

Publisher Elsevier

Specialty General Medicine

Date 2016 Jan 19

PMID 26777917

Citations 702

Authors

Michael J Owen

Akira Sawa

Preben B Mortensen

Affiliations

Soon will be listed here.

Abstract

Schizophrenia is a complex, heterogeneous behavioural and cognitive syndrome that seems to originate from disruption of brain development caused by genetic or environmental factors, or both. Dysfunction of dopaminergic neurotransmission contributes to the genesis of psychotic symptoms, but evidence also points to a widespread and variable involvement of other brain areas and circuits. Disturbances of synaptic function might underlie abnormalities of neuronal connectivity that possibly involves interneurons, but the precise nature, location, and timing of these events are uncertain. At present, treatment mainly consists of antipsychotic drugs combined with psychological therapies, social support, and rehabilitation, but a pressing need for more effective treatments and delivery of services exists. Advances in genomics, epidemiology, and neuroscience have led to great progress in understanding the disorder, and the opportunities for further scientific breakthrough are numerous--but so are the challenges.

Citing Articles

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Heda V, Dogra S, Kouznetsova V, Kumar A, Kesari S, Tsigelny I Int J Mol Sci. 2025; 26(5).

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Factors Contributing to Sexual Dysfunction in Female Schizophrenia Patients During Recovery: A Multifactorial Analysis.

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Identification of Hub Genes Involved in Early-onset Schizophrenia: From Genetic Susceptibility to Predicted Regulated Gene Expression.

Jen Y, Yu S, Hsiao P, Kuo P, Liu C, Liu C Res Sq. 2025; .

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