Differential MiRNA Expression in the Three-spined Stickleback, Response to Environmental Changes

Overview

Journal Sci Rep

Specialty Science

Date 2017 Dec 24

PMID 29273769

Citations 8

Authors

S M Rastorguev

A V Nedoluzhko

N M Gruzdeva

E S Boulygina

F S Sharko

A S Ibragimova

S V Tsygankova

A V Artemov

K G Skryabin

E B Prokhortchouk

Affiliations

Soon will be listed here.

Abstract

miRNAs play important role in the various physiological and evolutionary processes, however, there is no data allowing comparison of evolutionary differences between various ecotypes adapted to different environmental conditions and specimen demonstrating immediate physiological response to the environmental changes. We compared miRNA expression profiles between marine and freshwater stickleback populations of the three-spined stickleback to identify the evolutionary differences. To study the immediate physiological response to foreign environment, we explored the changes induced by transfer of marine sticklebacks into freshwater environment and vice versa. Comparative analysis of changes in miRNA expression suggested that they are driven by three independent factors: (1) non-specific changes in miRNA expression under different environmental conditions; (2) specific response to freshwater conditions in the marine stickleback ecotype; (3) specific response to extreme osmotic conditions for both marine and freshwater ecotypes during the contact with non-native environment. Gene Ontology enrichment analysis of differential expressed miRNA targets supports our current hypothesis.

Citing Articles

The interplay between epigenomic and transcriptomic variation during ecotype divergence in stickleback.

Luo M, Zhao J, Merila J, Barrett R, Guo B, Hu J BMC Biol. 2025; 23(1):70.

PMID: 40038570 PMC: 11881503. DOI: 10.1186/s12915-025-02176-0.

Sea of opportunities: marine genomics in an era of global environmental change.

Nedoluzhko A BMC Genomics. 2023; 24(1):286.

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High Nucleotide Diversity Accompanies Differential DNA Methylation in Naturally Diverging Populations.

Ord J, Gossmann T, Adrian-Kalchhauser I Mol Biol Evol. 2023; 40(4).

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Genomic Signatures of Freshwater Adaptation in Pacific Herring ().

Nedoluzhko A, Orlova S, Kurnosov D, Orlov A, Galindo-Villegas J, Rastorguev S Genes (Basel). 2022; 13(10).

PMID: 36292743 PMC: 9601299. DOI: 10.3390/genes13101856.

Genetic structure of marine and lake forms of Pacific herring .

Orlova S, Rastorguev S, Bagno T, Kurnosov D, Nedoluzhko A PeerJ. 2021; 9:e12444.

PMID: 34760402 PMC: 8570158. DOI: 10.7717/peerj.12444.

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