Gallbladder Volume and Emptying in Insulin-requiring Male Diabetics

Overview

Journal Dig Dis Sci

Specialty Gastroenterology

Date 1987 Aug 1

PMID 3301231

Citations 10

Authors

A Keshavarzian

M Dunne

F L Iber

Affiliations

Soon will be listed here.

Abstract

Gallbladder function was evaluated in 27 healthy male volunteers and 47 male insulin-requiring diabetics from a diabetic clinic. Three groups of patients were studied: 18 patients without neuropathy or retinopathy (A); 17 patients with evidence of peripheral neuropathy (B); and 12 patients with evidence of peripheral and autonomic neuropathy (C). Eleven patients complained of gastrointestinal symptoms (three in group B, eight in group C). Thirty minutes after a standard breakfast, fasting gallbladder volumes and gallbladder emptying rates were measured using a real-time mechanical sector ultrasound scanner. Fasting gallbladder volume in diabetic patients was similar to controls (24.9 +/- 2.7 N; 28.9 +/- 3.9 A; 23.7 +/- 2.2 B; 16.7 +/- 3.4 C ml mean +/- SEM). Postprandial gallbladder emptying was not significantly different in any groups (47.4 +/- 5.1% N; 43.2 +/- 7.7% A; 50.7 +/- 7.7% B; 46.8 +/- 11.1% C). Seven diabetics and two controls had poor gallbladder emptying. One screened patient had cholecystectomy, three patients had stones, and two had sludge with a thickened gallbladder wall for a total of 12.5% gallbladder disease. These data suggest that gallbladder dysfunction in male insulin-requiring diabetics is rare.

Citing Articles

Gallbladder hypomotility in diabetic polyneuropathy.

Varkonyi T, Lengyel C, Madacsy L, Velosy B, Kempler P, Fazekas T Clin Auton Res. 2002; 11(6):377-81.

PMID: 11794719 DOI: 10.1007/BF02292770.

Gallbladder volume: comparison of diabetics and controls.

Chapman B, Chapman T, Frampton C, Chisholm R, Allan R, Wilson I Dig Dis Sci. 1998; 43(2):344-8.

PMID: 9512128 DOI: 10.1023/a:1018810523399.

Gallbladder emptying and cholecystokinin and pancreatic polypeptide responses to a liquid meal in patients with diabetes mellitus.

Meguro T, Shimosegawa T, Satoh A, Suzuki H, Takasu A, Takayama A J Gastroenterol. 1997; 32(5):628-34.

PMID: 9349988 DOI: 10.1007/BF02934112.

Gallbladder motility change in late pregnancy and after delivery.

Hahm J, Park J, Song S, Cho Y, Moon K, Song Y Korean J Intern Med. 1997; 12(1):16-20.

PMID: 9159032 PMC: 4531973. DOI: 10.3904/kjim.1997.12.1.16.

Gallbladder dysfunction in diabetes mellitus.

Shaw S, Hajnal F, LEBOVITZ Y, Ralls P, Bauer M, Valenzuela J Dig Dis Sci. 1993; 38(3):490-6.

PMID: 8444081 DOI: 10.1007/BF01316504.

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