Bile Lipid Composition and Bile Acid Pool Size in Diabetes

Overview

Journal Am J Dig Dis

Specialty Gastroenterology

Date 1978 Aug 1

PMID 685938

Citations 24

Authors

M P de Leon

R Ferenderes

N Carulli

Affiliations

Soon will be listed here.

Abstract

Since the prevalence of gallstones is higher in diabetics than in controls and since cholelithiasis is often associated with supersaturated bile, we measured bile lipid composition and bile acid pool size in 8 patients with juvenile diabetes, 16 with maturity-onset diabetes, and 10 control subjects. Bile lipid composition was expressed as "saturation index." In the maturity-onset diabetics the saturation index (1.60 +/- 0.45 SDM) was significantly higher (P less than 0.005) than that in the controls (0.82 +/- 0.20) and in patients with juvenile diabetes (0.75 +/- 0.24). The absolute values for biliary bile acid concentration were significantly lower (P less than 0.01) in the maturity-onset diabetics than in the other two groups. There were no differences in either the proportion of the individual biliary bile acids or the size of the bile acid pool between the three groups. The results suggest that the incidence of cholelithiasis in diabetes is associated with the secretion of a supersaturated bile only in the maturity-onset subgroup.

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References

Pertsemlidis D, Panveliwalla D, AHRENS Jr E . Effects of clofibrate and of an estrogen-progestin combination on fasting biliary lipids and cholic acid kinetics in man. Gastroenterology. 1974; 66(4):565-73. View

ABEL L, LEVY B, Brodie B, KENDALL F . A simplified method for the estimation of total cholesterol in serum and demonstration of its specificity. J Biol Chem. 1952; 195(1):357-66. View

Friedman G, Kannel W, DAWBER T . The epidemiology of gallbladder disease: observations in the Framingham Study. J Chronic Dis. 1966; 19(3):273-92. DOI: 10.1016/0021-9681(66)90132-9. View

Ponz de Leon M, Ferenderes R, Carulli N . [Bile composition in patients with high risk of cholelithiasis]. Minerva Med. 1976; 67(53):3483-90. View

MALINS J, French J . Diabetic diarrhoea. Q J Med. 1957; 26(104):467-80. View

. Gallbladder disease as a side effect of drugs influencing lipid metabolism. Experience in the Coronary Drug Project. N Engl J Med. 1977; 296(21):1185-90. DOI: 10.1056/NEJM197705262962101. View

BARTLETT G . Phosphorus assay in column chromatography. J Biol Chem. 1959; 234(3):466-8. View

Cooper J, Geizerova H, Oliver M . Letter: Clofibrate and gallstones. Lancet. 1975; 1(7915):1083. DOI: 10.1016/s0140-6736(75)91845-0. View

Redinger R, Small D . Bile composition, bile salt metabolism and gallstones. Arch Intern Med. 1972; 130(4):618-30. View

10.

ZAHOR A, Sternby N, Kagan A, Uemura K, VANECEK R, Vichert A . Frequency of cholelithiasis in Prague and Malmö. An autopsy study. Scand J Gastroenterol. 1974; 9(1):3-7. View

11.

Lieber M . The incidence of gallstones and their correlation with other diseases. Ann Surg. 1952; 135(3):394-405. PMC: 1802325. DOI: 10.1097/00000658-195203000-00011. View

12.

Comess L, BENNETT P, Burch T . Clinical gallbladder disease in Pima Indians. Its high prevalence in contrast to Framingham, Massachusetts. N Engl J Med. 1967; 277(17):894-8. DOI: 10.1056/NEJM196710262771702. View

13.

Thomas P, Hofmann A . Letter: A simple calculation of the lithogenic index of bile: expressing biliary lipid composition on rectangular coordinates. Gastroenterology. 1973; 65(4):698-700. View

14.

HOLZBACH R, Marsh M, Olszewski M, Holan K . Cholesterol solubility in bile. Evidence that supersaturated bile is frequent in healthy man. J Clin Invest. 1973; 52(6):1467-79. PMC: 302412. DOI: 10.1172/JCI107321. View

15.

Trash D, Ross P, Murison J, Bouchier I . Proceedings: The influence of age on cholesterol saturation of bile. Gut. 1976; 17(5):394. View

16.

Freeman J, Meyer P, Printen K, Mason E, Denbesten L . Analysis of gallbladder bile in morbid obesity. Am J Surg. 1975; 129(2):163-6. DOI: 10.1016/0002-9610(75)90292-5. View

17.

. Prevalence of gall stones in Dundee: a necropsy study. Br Med J. 1975; 4(5994):427-30. PMC: 1675416. DOI: 10.1136/bmj.4.5994.427. View

18.

Sampliner R, BENNETT P, Comess L, ROSE F, Burch T . Gallbladder disease in pima indians. Demonstration of high prevalence and early onset by cholecystography. N Engl J Med. 1970; 283(25):1358-64. DOI: 10.1056/NEJM197012172832502. View

19.

van Berge Henegouwen G, Ruben A, BRANDT K . Quantitative analysis of bile acids in serum and bile, using gas--liquid chromatography. Clin Chim Acta. 1974; 54(3):249-61. DOI: 10.1016/0009-8981(74)90243-5. View

20.

Hofmann A . Bile acid malabsorption caused by ileal resection. Arch Intern Med. 1972; 130(4):597-605. View