Neurohumoral Control of Gallbladder Motility in Healthy Subjects and Diabetic Patients with or Without Autonomic Neuropathy

Overview

Journal Dig Dis Sci

Specialty Gastroenterology

Date 1990 Sep 1

PMID 2202570

Citations 11

Authors

S Fiorucci

R Bosso

L Scionti

S DiSanto

B Annibale

G Delle Fave

A Morelli

Affiliations

Soon will be listed here.

Abstract

Patients affected by diabetes mellitus are reported to have an increased incidence of gallbladder abnormalities. The pathophysiologic mechanisms for this phenomenon are unclear. In the present study ultrasonography was used to determine gallbladder emptying in response to a meal or separate cephalic or hormonal stimulation in 21 diabetic patients and 10 healthy subjects. Gallbladder emptying and refilling after a meal were similar in diabetic patients and healthy subjects. When diabetics were divided according to the presence or absence of cardiac autonomic neuropathy (AN), a significant reduction of gallbladder emptying in response to cephalic stimulation was found in diabetics with AN (P less than 0.01 in comparison with diabetics without AN or healthy subjects). A dose-response curve of gallbladder emptying in response cerulein, a cholecystokinin analog, at concentrations of 0.25, 1, and 4 micrograms/kg/min was evaluated. No differences of gallbladder emptying were found in the three groups of subjects, indicating that gallbladder sensitivity to hormonal stimulation is not changed in diabetic patients with or without AN. Diabetic patients with AN have a significant reduction of gastric acid output and pancreatic polypeptide (PP) secretion in response to cephalic stimulation (P less than 0.05 in comparison with diabetic patients without AN or healthy subjects). Cerulein-induced PP secretion was similar in all three groups of subjects (P greater than 0.05). This study indicates that in diabetic patients with AN, gallbladder emptying as well as gastric acid and PP secretions induced by neural stimulation are markedly reduced in comparison to diabetics without AN.

Citing Articles

Influence of gastric inhibitory polypeptide on pentagastrin-stimulated gastric acid secretion in patients with type 2 diabetes and healthy controls.

Meier J, Nauck M, Kask B, Holst J, Deacon C, Schmidt W World J Gastroenterol. 2006; 12(12):1874-80.

PMID: 16609993 PMC: 4087512. DOI: 10.3748/wjg.v12.i12.1874.

Gallbladder hypomotility in diabetic polyneuropathy.

Varkonyi T, Lengyel C, Madacsy L, Velosy B, Kempler P, Fazekas T Clin Auton Res. 2002; 11(6):377-81.

PMID: 11794719 DOI: 10.1007/BF02292770.

Cholelithiasic disease and associated factors in a Spanish population.

Devesa F, Ferrando J, Caldentey M, Borghol A, Moreno M, Nolasco A Dig Dis Sci. 2001; 46(7):1424-36.

PMID: 11478494 DOI: 10.1023/a:1010631619162.

Gallbladder volume: comparison of diabetics and controls.

Chapman B, Chapman T, Frampton C, Chisholm R, Allan R, Wilson I Dig Dis Sci. 1998; 43(2):344-8.

PMID: 9512128 DOI: 10.1023/a:1018810523399.

Gallbladder emptying and cholecystokinin and pancreatic polypeptide responses to a liquid meal in patients with diabetes mellitus.

Meguro T, Shimosegawa T, Satoh A, Suzuki H, Takasu A, Takayama A J Gastroenterol. 1997; 32(5):628-34.

PMID: 9349988 DOI: 10.1007/BF02934112.

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