The Intriguing Interaction of Escherichia Coli with the Host Environment and Innovative Strategies To Interfere with Colonization: a Summary of the 2019 E. Coli and the Mucosal Immune System Meeting

Overview

Journal Appl Environ Microbiol

Specialties Environmental Health
Microbiology

Date 2020 Oct 3

PMID 33008822

Authors

Eric Cox

Meryem Aloulou

James M Fleckenstein

Christina Schaffer

Asa Sjoling

Stephanie Schuller

Kurt Hanevik

Bert Devriendt

Weiping Zhang

Ann-Mari Svennerholm

Edward G Dudley

Affiliations

Soon will be listed here.

Abstract

The third and the Mucosal Immune System (ECMIS) meeting was held at Ghent University in Belgium from 2 to 5 June 2019. It brought together an international group of scientists interested in mechanisms of colonization, host response, and vaccine development. ECMIS distinguishes itself from related meetings on these enteropathogens by providing a greater emphasis on animal health and disease and covering a broad range of pathotypes, including enterohemorrhagic, enteropathogenic, enterotoxigenic, enteroaggregative, and extraintestinal pathogenic As it is well established that the genus represents a subspecies of , these organisms along with related enteroinvasive are also included. In addition, , a periodontal pathogen, was presented as an example of a pathogen which uses its surface glycans for mucosal interaction. This review summarizes several highlights from the 2019 meeting and major advances to our understanding of the biology of these pathogens and their impact on the host.

References

Tsuji M, Komatsu N, Kawamoto S, Suzuki K, Kanagawa O, Honjo T . Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches. Science. 2009; 323(5920):1488-92. DOI: 10.1126/science.1169152. View

Belotserkovsky I, Brunner K, Pinaud L, Rouvinski A, Dellarole M, Baron B . Glycan-Glycan Interaction Determines Tropism toward Human T Lymphocytes. mBio. 2018; 9(1). PMC: 5821077. DOI: 10.1128/mBio.02309-17. View

Joffre E, Nicklasson M, Alvarez-Carretero S, Xiao X, Sun L, Nookaew I . The bile salt glycocholate induces global changes in gene and protein expression and activates virulence in enterotoxigenic Escherichia coli. Sci Rep. 2019; 9(1):108. PMC: 6331568. DOI: 10.1038/s41598-018-36414-z. View

Devriendt B, De Geest B, Goddeeris B, Cox E . Crossing the barrier: Targeting epithelial receptors for enhanced oral vaccine delivery. J Control Release. 2012; 160(3):431-9. DOI: 10.1016/j.jconrel.2012.02.006. View

King C, Desai H, Sylvetsky A, LoTempio J, Ayanyan S, Carrie J . Baseline human gut microbiota profile in healthy people and standard reporting template. PLoS One. 2019; 14(9):e0206484. PMC: 6738582. DOI: 10.1371/journal.pone.0206484. View

Albenberg L, Esipova T, Judge C, Bittinger K, Chen J, Laughlin A . Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota. Gastroenterology. 2014; 147(5):1055-63.e8. PMC: 4252572. DOI: 10.1053/j.gastro.2014.07.020. View

Urdaneta V, Casadesus J . Interactions between Bacteria and Bile Salts in the Gastrointestinal and Hepatobiliary Tracts. Front Med (Lausanne). 2017; 4:163. PMC: 5632352. DOI: 10.3389/fmed.2017.00163. View

Bloch S, Zwicker S, Bostanci N, Sjoling A, Bostrom E, Belibasakis G . Immune response profiling of primary monocytes and oral keratinocytes to different Tannerella forsythia strains and their cell surface mutants. Mol Oral Microbiol. 2017; 33(2):155-167. DOI: 10.1111/omi.12208. View

Zhang W, Sack D . Current Progress in Developing Subunit Vaccines against Enterotoxigenic Escherichia coli-Associated Diarrhea. Clin Vaccine Immunol. 2015; 22(9):983-91. PMC: 4550667. DOI: 10.1128/CVI.00224-15. View

10.

Fleckenstein J, Kuhlmann F . Enterotoxigenic Escherichia coli Infections. Curr Infect Dis Rep. 2019; 21(3):9. PMC: 6508951. DOI: 10.1007/s11908-019-0665-x. View

11.

Coddens A, Diswall M, Angstrom J, Breimer M, Goddeeris B, Cox E . Recognition of blood group ABH type 1 determinants by the FedF adhesin of F18-fimbriated Escherichia coli. J Biol Chem. 2009; 284(15):9713-26. PMC: 2665092. DOI: 10.1074/jbc.M807866200. View

12.

Faith J, Guruge J, Charbonneau M, Subramanian S, Seedorf H, Goodman A . The long-term stability of the human gut microbiota. Science. 2013; 341(6141):1237439. PMC: 3791589. DOI: 10.1126/science.1237439. View

13.

Koomey M . O-linked protein glycosylation in bacteria: snapshots and current perspectives. Curr Opin Struct Biol. 2019; 56:198-203. DOI: 10.1016/j.sbi.2019.03.020. View

14.

Ellis S, Yasir M, Browning D, Busby S, Schuller S . Oxygen and contact with human intestinal epithelium independently stimulate virulence gene expression in enteroaggregative Escherichia coli. Cell Microbiol. 2019; 21(6):e13012. PMC: 6563437. DOI: 10.1111/cmi.13012. View

15.

Schaffer C, Messner P . Emerging facets of prokaryotic glycosylation. FEMS Microbiol Rev. 2016; 41(1):49-91. PMC: 5266552. DOI: 10.1093/femsre/fuw036. View

16.

Cong Y, Feng T, Fujihashi K, Schoeb T, Elson C . A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota. Proc Natl Acad Sci U S A. 2009; 106(46):19256-61. PMC: 2780781. DOI: 10.1073/pnas.0812681106. View

17.

Mosso H, Xiaoli L, Banerjee K, Hoffmann M, Yao K, Dudley E . A Putative Microcin Amplifies Shiga Toxin 2a Production of Escherichia coli O157:H7. J Bacteriol. 2019; 202(1). PMC: 6932236. DOI: 10.1128/JB.00353-19. View

18.

Hamner S, McInnerney K, Williamson K, Franklin M, Ford T . Bile salts affect expression of Escherichia coli O157:H7 genes for virulence and iron acquisition, and promote growth under iron limiting conditions. PLoS One. 2013; 8(9):e74647. PMC: 3769235. DOI: 10.1371/journal.pone.0074647. View

19.

Lundgren A, Bourgeois L, Carlin N, Clements J, Gustafsson B, Hartford M . Safety and immunogenicity of an improved oral inactivated multivalent enterotoxigenic Escherichia coli (ETEC) vaccine administered alone and together with dmLT adjuvant in a double-blind, randomized, placebo-controlled Phase I study. Vaccine. 2014; 32(52):7077-84. DOI: 10.1016/j.vaccine.2014.10.069. View

20.

Mani S, Toapanta F, McArthur M, Qadri F, Svennerholm A, Devriendt B . Role of antigen specific T and B cells in systemic and mucosal immune responses in ETEC and Shigella infections, and their potential to serve as correlates of protection in vaccine development. Vaccine. 2019; 37(34):4787-4793. PMC: 7413037. DOI: 10.1016/j.vaccine.2019.03.040. View