A Dominant, Coordinated T Regulatory Cell-IgA Response to the Intestinal Microbiota

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2009 Nov 6

PMID 19889972

Citations 242

Authors

Yingzi Cong

Ting Feng

Kohtaro Fujihashi

Trenton R Schoeb

Charles O Elson

Affiliations

Soon will be listed here.

Abstract

A T cell receptor transgenic mouse line reactive to a microbiota flagellin, CBir1, was used to define mechanisms of host microbiota homeostasis. Intestinal IgA, but not serum IgA, was found to block mucosal flagellin uptake and systemic T cell activation in mice. Depletion of CD4(+)CD25(+) Tregs decreased IgA(+) B cells, total IgA, and CBir1-specific IgA in gut within days. Repletion of T cell-deficient mice with either CD4(+)CD25(+) or CD4(+)foxp3(+) Tregs restored intestinal IgA to a much greater extent than their reciprocal CD4(+) subsets, indicating that Tregs are the major helper cells for IgA responses to microbiota antigens such as flagellin. We propose that the major role of this coordinated Treg-IgA response is to maintain commensalism with the microbiota.

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