A New Approach for the Diagnosis of Systemic and Oral Diseases Based on Salivary Biomolecules

Overview

Journal Dis Markers

Publisher Wiley

Specialty Biochemistry

Date 2019 Mar 26

PMID 30906485

Citations 33

Authors

Alexandra Roi

Laura C Rusu

Ciprian I Roi

Ruxandra E Luca

Simina Boia

Roxana I Munteanu

Affiliations

Soon will be listed here.

Abstract

Early diagnosis represents the target of contemporary medicine and has an important role in the prognosis and further treatment. Saliva is a biofluid that generated a high interest among researchers due to its multiple advantages over other body fluids. The multitude of components that can act as biomarkers influenced the existing technologies to develop protocols that could allow saliva to become the new noninvasive diagnostic method. Saliva as a diagnostic tool can bring substantial addition to the diagnostic armamentarium, providing important information about oral and general health. The diagnostic applications of saliva extended and had a rapid evolution due to the advancement in salivaomics. The present review summarizes the latest researches in saliva-related studies and explores the information and correlations that saliva can offer regarding the systemic and oral diseases, highlighting its great potential of diagnosis. It is expected that in the future specific guidelines and results regarding the salivary diagnostics are to be available, together with high-sensitivity and specificity tests for multiple systemic and oral diseases.

Citing Articles

Salivary Metabolomics as a Diagnostic Tool: Distinct Metabolic Profiles Across Orofacial Pain Subtypes.

Jasinska W, Birenzweig Y, Sharav Y, Aframian D, Rettman A, Hanut A Int J Mol Sci. 2025; 26(5).

PMID: 40076882 PMC: 11900362. DOI: 10.3390/ijms26052260.

Saliva as a Diagnostic Tool for Systemic Diseases-A Narrative Review.

Surdu A, Foia L, Luchian I, Trifan D, Tatarciuc M, Scutariu M Medicina (Kaunas). 2025; 61(2).

PMID: 40005360 PMC: 11857487. DOI: 10.3390/medicina61020243.

Changes in salivary biomarkers of burning mouth syndrome patients after clonazepam treatment.

Jang S, Kim J, Lee Y, Jung W J Oral Facial Pain Headache. 2025; 38(2):111-118.

PMID: 39801101 PMC: 11810660. DOI: 10.22514/jofph.2024.019.

The Variability of the Salivary Antimicrobial Peptide Profile: Impact of Lifestyle.

Gallo M, Ferrari E, Giovati L, Pertinhez T, Artesani L, Conti S Int J Mol Sci. 2024; 25(21).

PMID: 39519054 PMC: 11547034. DOI: 10.3390/ijms252111501.

Dysregulation of a Heme Oxygenase-Synuclein Axis in Parkinson Disease.

Cressatti M, Schipper H NeuroSci. 2024; 3(2):284-299.

PMID: 39483365 PMC: 11523740. DOI: 10.3390/neurosci3020020.

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