An Update on the Use of Inositols in Preventing Gestational Diabetes Mellitus (GDM) and Neural Tube Defects (NTDs)

Overview

Journal Expert Opin Drug Metab Toxicol

Publisher Informa Healthcare

Specialties Endocrinology
Pharmacology
Toxicology

Date 2020 Sep 23

PMID 32966143

Citations 17

Authors

Fabio Facchinetti

Pietro Cavalli

Andrew J Copp

Rosario DAnna

Eleni Kandaraki

Nicholas D E Greene

Vittorio Unfer

Affiliations

Soon will be listed here.

Abstract

Introduction: Obstetric history and maternal body composition and lifestyle may be associated with serious complications both for the mother, such as gestational diabetes mellitus (GDM), and for the fetus, including congenital malformations such as neural tube defects (NTDs).

Areas Covered: In view of the recent knowledge, changes in nutritional and physical activity habits ameliorate glycemic control during pregnancy and in turn improve maternal and neonatal health outcomes. Recently, a series of small clinical and experimental studies indicated that supplemenation with inositols, a family of insulin sensitizers, was associated with beneficial impact for both GDM and NTDs.

Expert Opinion: Herein, we discuss the most significant scientific evidence supporting myo-inositol administration as a prophylaxis for the above-mentioned conditions.

Citing Articles

Medical nutrition therapy in physiological pregnancy and in pregnancy complicated by obesity and/or diabetes: SID-AMD recommendations.

Lapolla A, Dalfra M, Marelli G, Parrillo M, Sciacca L, Sculli M Acta Diabetol. 2025; .

PMID: 39841216 DOI: 10.1007/s00592-024-02442-7.

Inositols and female reproduction disorders: a consensus statement from the working group of the Club of the Italian Society of Endocrinology (SIE)-Women's Endocrinology.

Moretti C, Bonomi M, Dionese P, Federici S, Fulghesu A, Giannelli J J Endocrinol Invest. 2024; 47(9):2111-2141.

PMID: 39009925 DOI: 10.1007/s40618-024-02363-w.

Inpp5e Regulated the Cilium-Related Genes Contributing to the Neural Tube Defects Under 5-Fluorouracil Exposure.

Wang X, Yu J, Yue H, Li S, Yang A, Zhu Z Mol Neurobiol. 2024; 61(9):6189-6199.

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A Markov-model simulation of IVF programs for PCOS patients indicates that coupling myo-Inositol with rFSH is cost-effective for the Italian Health System.

Beresniak A, Russo M, Forte G, Lagana A, Oliva M, Aragona C Sci Rep. 2023; 13(1):17789.

PMID: 37853019 PMC: 10584971. DOI: 10.1038/s41598-023-44055-0.

Inositol supplementation for the prevention and treatment of gestational diabetes mellitus: a meta-analysis of randomized controlled trials.

Li C, Shi H Arch Gynecol Obstet. 2023; 309(5):1959-1969.

PMID: 37308791 DOI: 10.1007/s00404-023-07100-x.

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