Access to Highly Substituted Oxazoles by the Reaction of α-azidochalcone with Potassium Thiocyanate

Overview

Journal Beilstein J Org Chem

Specialty Chemistry

Date 2020 Sep 21

PMID 32952727

Authors

Mysore Bhyrappa Harisha

Pandi Dhanalakshmi

Rajendran Suresh

Raju Ranjith Kumar

Shanmugam Muthusubramanian

Affiliations

Soon will be listed here.

Abstract

The reactivity of α-azidochalcones has been explored for the preparation of highly substituted oxazoles via a 2-azirine intermediate. The azidochalcones, when treated with potassium thiocyanate in the presence of potassium persulfate, lead to 2,4,5-trisubstituted oxazoles in good yields. Incidentally, 2-aminothiazoles are the products when ferric nitrate is employed instead of persulfate in the above reaction.

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