Development of a Method for the Synthesis of 2,4,5-trisubstituted Oxazoles Composed of Carboxylic Acid, Amino Acid, and Boronic Acid

Overview

Journal Beilstein J Org Chem

Specialty Chemistry

Date 2017 Aug 29

PMID 28845191

Citations 1

Authors

Kohei Yamada

Naoto Kamimura

Munetaka Kunishima

Affiliations

Soon will be listed here.

Abstract

A novel method for the synthesis of trisubstituted oxazoles via a one-pot oxazole synthesis/Suzuki-Miyaura coupling sequence has been developed. One-pot formation of 5-(triazinyloxy)oxazoles using carboxylic acids, amino acids and a dehydrative condensing reagent, DMT-MM, followed by Ni-catalyzed Suzuki-Miyaura coupling with boronic acids provided the corresponding 2,4,5-trisubstituted oxazoles in good yields.

Citing Articles

Access to highly substituted oxazoles by the reaction of α-azidochalcone with potassium thiocyanate.

Harisha M, Dhanalakshmi P, Suresh R, Ranjith Kumar R, Muthusubramanian S Beilstein J Org Chem. 2020; 16:2108-2118.

PMID: 32952727 PMC: 7476590. DOI: 10.3762/bjoc.16.178.

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