Identification of Simple Compounds with Microtubule-Binding Activity That Inhibit Cancer Cell Growth with High Potency

Overview

Journal ACS Med Chem Lett

Publisher American Chemical Society

Specialty Chemistry

Date 2012 Jan 17

PMID 22247791

Citations 25

Authors

Wan Seok Yang

Kenichi Shimada

Darnelle Delva

Milesh Patel

Egberamwen Ode

Rachid Skouta

Brent R Stockwell

Affiliations

Soon will be listed here.

Abstract

We analyzed more than 1 million small molecules with the goal of finding simple synthetic compounds that potently inhibit cancer cell growth. We identified three such compounds with unknown mechanisms of action. Subsequent studies revealed that all three of these small molecules target microtubules. These three scaffolds can serve as templates for developing new microtubule-targeted agents, overcoming the limits of existing microtubule-inhibiting drugs derived from complex natural products.

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