Antimicrobial Peptides - Advances in Development of Therapeutic Applications

Overview

Journal Life Sci

Publisher Elsevier

Specialties Biochemistry
Biology
Physiology

Date 2020 Sep 15

PMID 32931796

Citations 84

Authors

Huy Xuan Luong

Tung Truong Thanh

Tuan Hiep Tran

Affiliations

Soon will be listed here.

Abstract

The severe infection is becoming a significant health problem which threaten the lives of patients and the safety and economy of society. In the way of finding new strategy, antimicrobial peptides (AMPs) - an important part of host defense family, emerged with tremendous potential. Up to date, huge numbers of AMPs has been investigated from both natural and synthetic sources showing not only the ability to kill microbial pathogens but also propose other benefits such as wound healing, anti-tumor, immune modulation. In this review, we describe the involvements of AMPs in biological systems and discuss the opportunity in developing AMPs for clinical applications. In the detail, their properties in antibacterial activity is followed by their application in some infection diseases and cancer. The key discussions are the approaches to improve biological activities of AMPs either by modifying chemical structure or incorporating into delivery systems. The new applications and perspectives for the future of AMPs would open the new era of their development.

Citing Articles

Computational analysis of antimicrobial peptides targeting key receptors in infection-related cardiovascular diseases: molecular docking and dynamics insights.

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Antimicrobial peptide biological activity, delivery systems and clinical translation status and challenges.

Zheng S, Tu Y, Li B, Qu G, Li A, Peng X J Transl Med. 2025; 23(1):292.

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Biochemistry of Bacterial Biofilm: Insights into Antibiotic Resistance Mechanisms and Therapeutic Intervention.

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Plant Antimicrobial Peptides and Their Main Families and Roles: A Review of the Literature.

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Immunomodulatory peptides: new therapeutic horizons for emerging and re-emerging infectious diseases.

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