Kaempferol As a Dietary Anti-Inflammatory Agent: Current Therapeutic Standing

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2020 Sep 10

PMID 32906577

Citations 112

Authors

Waqas Alam

Haroon Khan

Muhammad Ajmal Shah

Omar Cauli

Luciano Saso

Affiliations

Soon will be listed here.

Abstract

Inflammation is a physiological response to different pathological, cellular or vascular damages due to physical, chemical or mechanical trauma. It is characterized by pain, redness, heat and swelling. Current natural drugs are carefully chosen as a novel therapeutic strategy for the management of inflammatory diseases. Different phytochemical constituents are present in natural products. These phytochemicals have high efficacy both in vivo and in vitro. Among them, flavonoids occur in many foods, vegetables and herbal medicines and are considered as the most active constituent, having the ability to attenuate inflammation. Kaempferol is a polyphenol that is richly found in fruits, vegetables and herbal medicines. It is also found in plant-derived beverages. Kaempferol is used in the management of various ailments but there is no available review article that can summarize all the natural sources and biological activities specifically focusing on the anti-inflammatory effect of kaempferol. Therefore, this article is aimed at providing a brief updated review of the literature regarding the anti-inflammatory effect of kaempferol and its possible molecular mechanisms of action. Furthermore, the review provides the available updated literature regarding the natural sources, chemistry, biosynthesis, oral absorption, metabolism, bioavailability and therapeutic effect of kaempferol.

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References

Kong L, Luo C, Li X, Zhou Y, He H . The anti-inflammatory effect of kaempferol on early atherosclerosis in high cholesterol fed rabbits. Lipids Health Dis. 2013; 12:115. PMC: 3735477. DOI: 10.1186/1476-511X-12-115. View

Manach C, Scalbert A, Morand C, Remesy C, Jimenez L . Polyphenols: food sources and bioavailability. Am J Clin Nutr. 2004; 79(5):727-47. DOI: 10.1093/ajcn/79.5.727. View

Mira L, Fernandez M, Santos M, Rocha R, Florencio M, Jennings K . Interactions of flavonoids with iron and copper ions: a mechanism for their antioxidant activity. Free Radic Res. 2003; 36(11):1199-208. DOI: 10.1080/1071576021000016463. View

Fantone J, Ward P . Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions. Am J Pathol. 1982; 107(3):395-418. PMC: 1916241. View

durackova Z . Some current insights into oxidative stress. Physiol Res. 2009; 59(4):459-469. DOI: 10.33549/physiolres.931844. View

Navarro S, Schwarz Y, Song X, Wang C, Chen C, Trudo S . Cruciferous vegetables have variable effects on biomarkers of systemic inflammation in a randomized controlled trial in healthy young adults. J Nutr. 2014; 144(11):1850-7. PMC: 4195422. DOI: 10.3945/jn.114.197434. View

de Vries J, Hollman P, Meyboom S, Buysman M, Zock P, van Staveren W . Plasma concentrations and urinary excretion of the antioxidant flavonols quercetin and kaempferol as biomarkers for dietary intake. Am J Clin Nutr. 1998; 68(1):60-5. DOI: 10.1093/ajcn/68.1.60. View

Sharma J, Mohammed L . The role of leukotrienes in the pathophysiology of inflammatory disorders: is there a case for revisiting leukotrienes as therapeutic targets?. Inflammopharmacology. 2006; 14(1-2):10-6. DOI: 10.1007/s10787-006-1496-6. View

Silva I, Rodrigues A, Gaspar J, Maia R, Laires A, Rueff J . Mutagenicity of kaempferol in V79 cells: the role of cytochromes P450. Teratog Carcinog Mutagen. 1996; 16(4):229-41. DOI: 10.1002/(SICI)1520-6866(1996)16:4<229::AID-TCM4>3.0.CO;2-K. View

10.

Hakkinen S, Karenlampi S, Heinonen I, Mykkanen H, Torronen A . Content of the flavonols quercetin, myricetin, and kaempferol in 25 edible berries. J Agric Food Chem. 2000; 47(6):2274-9. DOI: 10.1021/jf9811065. View

11.

Raso G, Meli R, Di Carlo G, Pacilio M, Di Carlo R . Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1. Life Sci. 2001; 68(8):921-31. DOI: 10.1016/s0024-3205(00)00999-1. View

12.

. Biosynthesis of flavonoids and effects of stress. Curr Opin Plant Biol. 2002; 5(3):218-23. DOI: 10.1016/s1369-5266(02)00256-x. View

13.

Nair M, Mahajan S, Reynolds J, Aalinkeel R, Nair H, Schwartz S . The flavonoid quercetin inhibits proinflammatory cytokine (tumor necrosis factor alpha) gene expression in normal peripheral blood mononuclear cells via modulation of the NF-kappa beta system. Clin Vaccine Immunol. 2006; 13(3):319-28. PMC: 1391952. DOI: 10.1128/CVI.13.3.319-328.2006. View

14.

Havsteen B . The biochemistry and medical significance of the flavonoids. Pharmacol Ther. 2002; 96(2-3):67-202. DOI: 10.1016/s0163-7258(02)00298-x. View

15.

Francis A, Shetty T, Bhattacharya R . Modulating effect of plant flavonoids on the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine. Carcinogenesis. 1989; 10(10):1953-5. DOI: 10.1093/carcin/10.10.1953. View

16.

Funk C . Prostaglandins and leukotrienes: advances in eicosanoid biology. Science. 2001; 294(5548):1871-5. DOI: 10.1126/science.294.5548.1871. View

17.

Bokkenheuser V, Shackleton C, Winter J . Hydrolysis of dietary flavonoid glycosides by strains of intestinal Bacteroides from humans. Biochem J. 1987; 248(3):953-6. PMC: 1148642. DOI: 10.1042/bj2480953. View

18.

Li C, Li X, Choi J . Enhanced bioavailability of etoposide after oral or intravenous administration of etoposide with kaempferol in rats. Arch Pharm Res. 2009; 32(1):133-8. DOI: 10.1007/s12272-009-1127-z. View

19.

DuPont M, Day A, Bennett R, Mellon F, Kroon P . Absorption of kaempferol from endive, a source of kaempferol-3-glucuronide, in humans. Eur J Clin Nutr. 2004; 58(6):947-54. DOI: 10.1038/sj.ejcn.1601916. View

20.

Hyun S, Jung H, Young Chung H, Choi J . In vitro peroxynitrite scavenging activity of 6-hydroxykynurenic acid and other flavonoids from Gingko biloba yellow leaves. Arch Pharm Res. 2007; 29(12):1074-9. DOI: 10.1007/BF02969294. View