The Flavonoid Quercetin Inhibits Proinflammatory Cytokine (tumor Necrosis Factor Alpha) Gene Expression in Normal Peripheral Blood Mononuclear Cells Via Modulation of the NF-kappa Beta System

Overview

Journal Clin Vaccine Immunol

Publisher American Society for Microbiology

Specialties Allergy & Immunology
Pathology

Date 2006 Mar 9

PMID 16522772

Citations 110

Authors

Madhavan P Nair

Supriya Mahajan

Jessica L Reynolds

Ravikumar Aalinkeel

Harikrishnan Nair

Stanley A Schwartz

Chithan Kandaswami

Affiliations

Soon will be listed here.

Abstract

The flavonoids comprise a large class of low-molecular-weight plant metabolites ubiquitously distributed in food plants. These dietary antioxidants exert significant antitumor, antiallergic, and anti-inflammatory effects. The molecular mechanisms of their biological effects remain to be clearly understood. We investigated the anti-inflammatory potentials of a safe, common dietary flavonoid component, quercetin, for its ability to modulate the production and gene expression of the proinflammatory cytokine tumor necrosis factor alpha (TNF-alpha) by human peripheral blood mononuclear cells (PBMC). Our results showed that quercetin significantly inhibited TNF-alpha production and gene expression in a dose-dependent manner. Our results provide direct evidence of the anti-inflammatory effects of quercetin by PBMC, which are mediated by the inhibition of the proinflammatory cytokine TNF-alpha via modulation of NF-kappabeta1 and Ikappabeta.

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