Cellular and Molecular Architecture of the Intestinal Stem Cell Niche

Overview

Journal Nat Cell Biol

Specialty Cell Biology

Date 2020 Sep 5

PMID 32884148

Citations 87

Authors

Neil McCarthy

Judith Kraiczy

Ramesh A Shivdasani

Affiliations

Soon will be listed here.

Abstract

Intestinal stem and progenitor cells replicate and differentiate in distinct compartments, influenced by Wnt, BMP, and other subepithelial cues. The cellular sources of these signals were long obscure because intestinal mesenchyme was insufficiently characterised. In this Review, we discuss how recent mRNA profiles of mouse and human intestinal submucosa, coupled with fine-resolution microscopy and gene and cell disruptions, reveal a coherent picture of an organised tissue carrying cells with distinct molecular properties and functions.

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