Harnessing 3D Models to Uncover the Mechanisms Driving Infectious and Inflammatory Disease in the Intestine

Overview

Journal BMC Biol

Publisher Biomed Central

Specialty Biology

Date 2024 Dec 30

PMID 39736603

Authors

Diana Micati

Sara Hlavca

Wing Hei Chan

Helen E Abud

Affiliations

Soon will be listed here.

Abstract

Representative models of intestinal diseases are transforming our knowledge of the molecular mechanisms of disease, facilitating effective drug screening and avenues for personalised medicine. Despite the emergence of 3D in vitro intestinal organoid culture systems that replicate the genetic and functional characteristics of the epithelial tissue of origin, there are still challenges in reproducing the human physiological tissue environment in a format that enables functional readouts. Here, we describe the latest platforms engineered to investigate environmental tissue impacts, host-microbe interactions and enable drug discovery. This highlights the potential to revolutionise knowledge on the impact of intestinal infection and inflammation and enable personalised disease modelling and clinical translation.

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