Targeted Metabolomics Analysis on Obstructive Sleep Apnea Patients After Multilevel Sleep Surgery

Overview

Journal Metabolites

Publisher MDPI

Date 2020 Sep 5

PMID 32882816

Citations 10

Authors

Abdulmohsen Alterki

Shibu Joseph

Thangavel Alphonse Thanaraj

Irina Al-Khairi

Preethi Cherian

Arshad Channanath

Devarajan Sriraman

Mahmoud A K Ebrahim

Alaaeldin Ibrahim

Ali Tiss

Fahd Al-Mulla

Anas M Abdel Rahman

Jehad Abubaker

Mohamed Abu-Farha

Affiliations

Soon will be listed here.

Abstract

Background: Obstructive sleep apnea (OSA) is caused by partial or complete obstruction of the upper airways. Corrective surgeries aim at removing obstructions in the nasopharynx, oropharynx, and hypopharynx. OSA is associated with an increased risk of various metabolic diseases. Our objective was to evaluate the effect of surgery on the plasma metabolome.

Methods: This study included 39 OSA patients who underwent Multilevel Sleep Surgery (MLS). Clinical and anthropometric measures were taken at baseline and five months after surgery.

Results: The mean Apnea-Hypopnea Index (AHI) significantly dropped from 22.0 ± 18.5 events/hour to 8.97 ± 9.57 events/hour (-Value < 0.001). Epworth's sleepiness Score (ESS) dropped from 12.8 ± 6.23 to 2.95 ± 2.40 (-Value < 0.001), indicating the success of the surgery in treating OSA. Plasma levels of metabolites, phosphocholines (PC) PC.41.5, PC.42.3, ceremide (Cer) Cer.44.0, and triglyceride (TG) TG.53.6, TG.55.6 and TG.56.8 were decreased (-Value < 0.05), whereas lysophosphatidylcholines (LPC) 20.0 and PC.39.3 were increased (-Value < 0.05) after surgery.

Conclusion: This study highlights the success of MLS in treating OSA. Treatment of OSA resulted in an improvement of the metabolic status that was characterized by decreased TG, PCs, and Cer metabolites after surgery, indicating that the success of the surgery positively impacted the metabolic status of these patients.

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