Study on the Levels of 25(OH)D, Inflammation Markers and Glucose and Fat Metabolism Indexes in Pregnant Women of Han Nationality in Jiangsu Province with Gestational Diabetes Mellitus

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2020 Sep 3

PMID 32871878

Citations 3

Authors

Liu Yaqiong

Wang Guohua

Yang Fuyan

Lu Wei

Shi Dan

Zhang Yi

Affiliations

Soon will be listed here.

Abstract

The aim of this study is to investigate the levels of 25(OH)D, inflammation markers and glucose and fat metabolism indexes in pregnant women with Gestational diabetes mellitus (GDM).One hundred and ten cases GDM and 100 cases healthy pregnant women in the First People's Hospital of Lianyungang City from October 2016 to December 2018 were recruited for this observational cross-sectional study. Each participant's anthropometric and demographic data was recorded. Blood samples were collected and analyzed to determine the levels of 25(OH)D, high sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-α), fasting blood glucose, fasting blood insulin, hemoglobin A1c (HbA1c), homeostasis model assessment of insulin resistance (HOMA-IR), cholesterol and triglycerides.Inflammatory markers and glucose and fat metabolism indexes were all significantly higher in the GDM group than that in the control group, while Serum 25(OH)D level in the GDM group was significantly lower. Serum 25(OH)D levels were negatively correlated with hs-CRP, while not with TNF-α. Furthermore, Serum 25(OH)D, hs-CRP and TNF-α levels were all associated with increased risk of developing GDM.Nowadays, the reports on the association between 25(OH)D level and GDM were controversial. Our results are consistent with the view that there was association between 25(OH)D level and GDM, and expand the literature by showing the roles of 25(OH)D, inflammation markers as well as glucose and fat metabolism indexes in the risk of developing GDM in the pregnant women with the low overall levels of 25(OH)D before delivery. This broadens our knowledge on the pathophysiology of GDM, which may be helpful in prevention and treatment of GDM.

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References

Eggemoen A, Waage C, Sletner L, Gulseth H, Birkeland K, Jenum A . Vitamin D, Gestational Diabetes, and Measures of Glucose Metabolism in a Population-Based Multiethnic Cohort. J Diabetes Res. 2018; 2018:8939235. PMC: 5933024. DOI: 10.1155/2018/8939235. View

Mousa A, Abell S, Scragg R, de Courten B . Vitamin D in Reproductive Health and Pregnancy. Semin Reprod Med. 2016; 34(2):e1-13. DOI: 10.1055/s-0036-1583529. View

Mugabo Y, Li L, Renier G . The connection between C-reactive protein (CRP) and diabetic vasculopathy. Focus on preclinical findings. Curr Diabetes Rev. 2009; 6(1):27-34. DOI: 10.2174/157339910790442628. View

Eklund C . Proinflammatory cytokines in CRP baseline regulation. Adv Clin Chem. 2009; 48:111-36. DOI: 10.1016/s0065-2423(09)48005-3. View

Rajput R, Vohra S, Nanda S, Rajput M . Severe 25(OH)vitamin-D deficiency: A risk factor for development of gestational diabetes mellitus. Diabetes Metab Syndr. 2019; 13(2):985-987. DOI: 10.1016/j.dsx.2019.01.004. View

Sacerdote A, Dave P, Lokshin V, Bahtiyar G . Type 2 Diabetes Mellitus, Insulin Resistance, and Vitamin D. Curr Diab Rep. 2019; 19(10):101. DOI: 10.1007/s11892-019-1201-y. View

Khambule L, George J . The Role of Inflammation in the Development of GDM and the Use of Markers of Inflammation in GDM Screening. Adv Exp Med Biol. 2019; 1134:217-242. DOI: 10.1007/978-3-030-12668-1_12. View

Bellia A, Garcovich C, DAdamo M, Lombardo M, Tesauro M, Donadel G . Serum 25-hydroxyvitamin D levels are inversely associated with systemic inflammation in severe obese subjects. Intern Emerg Med. 2011; 8(1):33-40. DOI: 10.1007/s11739-011-0559-x. View

Alyas S, Roohi N, Ashraf S, Ilyas S, Ilyas A . Early pregnancy biochemical markers of placentation for screening of gestational diabetes mellitus (GDM). Diabetes Metab Syndr. 2019; 13(4):2353-2356. DOI: 10.1016/j.dsx.2019.06.006. View

10.

Olmos-Ortiz A, Avila E, Durand-Carbajal M, Diaz L . Regulation of calcitriol biosynthesis and activity: focus on gestational vitamin D deficiency and adverse pregnancy outcomes. Nutrients. 2015; 7(1):443-80. PMC: 4303849. DOI: 10.3390/nu7010443. View

11.

Cannell J, Grant W, Holick M . Vitamin D and inflammation. Dermatoendocrinol. 2015; 6(1):e983401. PMC: 4580066. DOI: 10.4161/19381980.2014.983401. View

12.

Taschereau-Charron A, Da Silva M, Bilodeau J, Morisset A, Julien P, Rudkowska I . Alterations of fatty acid profiles in gestational diabetes and influence of the diet. Maturitas. 2017; 99:98-104. DOI: 10.1016/j.maturitas.2017.01.014. View

13.

Haidari F, Jalali M, Shahbazian N, Haghighizadeh M, Azadegan E . Comparison of Serum Levels of Vitamin D and Inflammatory Markers Between Women With Gestational Diabetes Mellitus and Healthy Pregnant Control. J Family Reprod Health. 2016; 10(1):1-8. PMC: 4930448. View

14.

Al-Shaikh G, Ibrahim G, Fayed A, Al-Mandeel H . Impact of vitamin D deficiency on maternal and birth outcomes in the Saudi population: a cross-sectional study. BMC Pregnancy Childbirth. 2016; 16:119. PMC: 4879737. DOI: 10.1186/s12884-016-0901-4. View

15.

Feng H, Zhu W, Yang H, Wei Y, Wang C, Su R . Relationship between Oral Glucose Tolerance Test Characteristics and Adverse Pregnancy Outcomes among Women with Gestational Diabetes Mellitus. Chin Med J (Engl). 2017; 130(9):1012-1018. PMC: 5421169. DOI: 10.4103/0366-6999.204928. View

16.

Zhu W, Yang H, Wei Y, Yan J, Wang Z, Li X . Evaluation of the value of fasting plasma glucose in the first prenatal visit to diagnose gestational diabetes mellitus in china. Diabetes Care. 2012; 36(3):586-90. PMC: 3579369. DOI: 10.2337/dc12-1157. View

17.

Moon R, Harvey N, Cooper C . ENDOCRINOLOGY IN PREGNANCY: Influence of maternal vitamin D status on obstetric outcomes and the fetal skeleton. Eur J Endocrinol. 2015; 173(2):R69-83. PMC: 4968635. DOI: 10.1530/EJE-14-0826. View

18.

Hauta-Alus H, Viljakainen H, Holmlund-Suila E, Enlund-Cerullo M, Rosendahl J, Valkama S . Maternal vitamin D status, gestational diabetes and infant birth size. BMC Pregnancy Childbirth. 2017; 17(1):420. PMC: 5732505. DOI: 10.1186/s12884-017-1600-5. View

19.

Borst S . The role of TNF-alpha in insulin resistance. Endocrine. 2004; 23(2-3):177-82. DOI: 10.1385/ENDO:23:2-3:177. View

20.

Zhang C, Rawal S, Chong Y . Risk factors for gestational diabetes: is prevention possible?. Diabetologia. 2016; 59(7):1385-1390. PMC: 6364673. DOI: 10.1007/s00125-016-3979-3. View