Relationship Between Oral Glucose Tolerance Test Characteristics and Adverse Pregnancy Outcomes Among Women with Gestational Diabetes Mellitus

Overview

Journal Chin Med J (Engl)

Specialty General Medicine

Date 2017 May 5

PMID 28469094

Citations 19

Authors

Hui Feng

Wei-Wei Zhu

Hui-Xia Yang

Yu-Mei Wei

Chen Wang

Ri-Na Su

Moshe Hod

Eran Hadar

Affiliations

Soon will be listed here.

Abstract

Background: Hyperglycemia is associated with adverse pregnancy outcomes. However, the relationships between them remain ambiguous. This study aimed to analyze the effect of different oral glucose tolerance test (OGTT) results on adverse perinatal outcomes.

Methods: This retrospective cohort study included data from 15 hospitals in Beijing from June 20, 2013 to November 30, 2013. Women with gestational diabetes mellitus (GDM) were categorized according to the number and distribution of abnormal OGTT values, and the characteristics of adverse pregnancy outcomes were evaluated. Chi-square test and logistic regression analysis were used to determine the associations.

Results: In total, 14,741 pregnant women were included in the study population, 2927 (19.86%) of whom had GDM. As the number of hyperglycemic values in the OGTT increased, the risk of cesarean delivery, preterm births, large-for-gestational age (LGA), macrosomia, and neonatal complications significantly increased. Fasting hyperglycemia had clear associations with macrosomia (odds ratios [OR s]:1.84, 95% confidence intervals [CI s]: 1.39-2.42,P < 0.001), LGA (OR: 1.70, 95% CI: 1.29-2.25,P < 0.001), and cesarean delivery (OR: 1.33, 95% CI: 1.15-1.55,P < 0.001). The associations were stronger as fasting glucose increased. GDM diagnosed by hyperglycemia at OGTT-2 h was more likely to lead to preterm birth (OR: 1.50, 95% CI: 1.11-2.03,P < 0.01).

Conclusions: Various characteristics of OGTTs are associated with different adverse outcomes. A careful reconsideration of GDM with hierarchical and individualized management according to OGTT characteristics is needed.

Citing Articles

Association between area under the curve of oral glucose tolerance test and the risk of preterm birth among women with gestational diabetes mellitus: a mediation effect of gestational weight gain.

Liu J, Li H, Wang X, Liu B, He D, Zhang G BMC Pregnancy Childbirth. 2025; 25(1):267.

PMID: 40069626 PMC: 11895138. DOI: 10.1186/s12884-025-07383-9.

Risk factors and diagnostic performance of predictors as a screening technique for gestational diabetes mellitus: a retrospective cross-sectional study.

Khobrani F, Alzahrani A, Binmahfoodh D, Hemedy R, Abbas S Ann Med Surg (Lond). 2024; 86(8):4384-4388.

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Evaluating the relationship between hepatitis B viral activity and gestational diabetes mellitus: A prospective cohort study.

Whyler N, Pyle A, Krishnaswamy S, Said J, Giles M Womens Health (Lond). 2024; 20:17455057241265083.

PMID: 39051642 PMC: 11273580. DOI: 10.1177/17455057241265083.

Dietary Intake and Oral Glucose Tolerance Test Results in Women with Gestational Diabetes.

Chagas L, Torloni M, Silva-Neto L, Dualib P, de Sousa R, Bittencourt J J Clin Med. 2024; 13(10).

PMID: 38792489 PMC: 11122252. DOI: 10.3390/jcm13102948.

Neonatal outcomes according to different glucose threshold values in gestational diabetes: a register-based study.

Kariniemi K, Vaarasmaki M, MaNnisto T, Mustaniemi S, Kajantie E, Etelainen S BMC Pregnancy Childbirth. 2024; 24(1):271.

PMID: 38609891 PMC: 11010296. DOI: 10.1186/s12884-024-06473-4.

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