The SNM1A DNA Repair Nuclease

Overview

Journal DNA Repair (Amst)

Publisher Elsevier

Specialties Biochemistry
Molecular Biology

Date 2020 Sep 1

PMID 32866775

Citations 15

Authors

Hannah T Baddock

Yuliana Yosaatmadja

Joseph A Newman

Christopher J Schofield

Opher Gileadi

Peter J McHugh

Affiliations

Soon will be listed here.

Abstract

Unrepaired, or misrepaired, DNA damage can contribute to the pathogenesis of a number of conditions, or disease states; thus, DNA damage repair pathways, and the proteins within them, are required for the safeguarding of the genome. Human SNM1A is a 5'-to-3' exonuclease that plays a role in multiple DNA damage repair processes. To date, most data suggest a role of SNM1A in primarily ICL repair: SNM1A deficient cells exhibit hypersensitivity to ICL-inducing agents (e.g. mitomycin C and cisplatin); and both in vivo and in vitro experiments demonstrate SNM1A and XPF-ERCC1 can function together in the 'unhooking' step of ICL repair. SNM1A further interacts with a number of other proteins that contribute to genome integrity outside canonical ICL repair (e.g. PCNA and CSB), and these may play a role in regulating SNM1As function, subcellular localisation, and post-translational modification state. These data also provide further insight into other DNA repair pathways to which SNM1A may contribute. This review aims to discuss all aspects of the exonuclease, SNM1A, and its contribution to DNA damage tolerance.

Citing Articles

SNM1A is crucial for efficient repair of complex DNA breaks in human cells.

Swift L, Lagerholm B, Henderson L, Ratnaweera M, Baddock H, Sengerova B Nat Commun. 2024; 15(1):5392.

PMID: 38918391 PMC: 11199599. DOI: 10.1038/s41467-024-49583-5.

Cell-active small molecule inhibitors validate the SNM1A DNA repair nuclease as a cancer target.

Bielinski M, Henderson L, Yosaatmadja Y, Swift L, Baddock H, Bowen M Chem Sci. 2024; 15(21):8227-8241.

PMID: 38817593 PMC: 11134331. DOI: 10.1039/d4sc00367e.

Replication-Independent ICL Repair: From Chemotherapy to Cell Homeostasis.

Ahmed A, Kato N, Gautier J J Mol Biol. 2024; 436(13):168618.

PMID: 38763228 PMC: 11227339. DOI: 10.1016/j.jmb.2024.168618.

DNA Damage Responses, the Trump Card of Stem Cells in the Survival Game.

Tayanloo-Beik A, Hamidpour S, Nikkhah A, Arjmand R, Mafi A, Rezaei-Tavirani M Adv Exp Med Biol. 2023; 1470:165-188.

PMID: 37923882 DOI: 10.1007/5584_2023_791.

Break-induced replication orchestrates resection-dependent template switching.

Zhang T, Rawal Y, Jiang H, Kwon Y, Sung P, Greenberg R Nature. 2023; 619(7968):201-208.

PMID: 37316655 PMC: 10937050. DOI: 10.1038/s41586-023-06177-3.

References

Daiyasu H, Osaka K, Ishino Y, Toh H . Expansion of the zinc metallo-hydrolase family of the beta-lactamase fold. FEBS Lett. 2001; 503(1):1-6. DOI: 10.1016/s0014-5793(01)02686-2. View

Muniandy P, Thapa D, Thazhathveetil A, Liu S, Seidman M . Repair of laser-localized DNA interstrand cross-links in G1 phase mammalian cells. J Biol Chem. 2009; 284(41):27908-27917. PMC: 2788842. DOI: 10.1074/jbc.M109.029025. View

Lopez-Martinez D, Liang C, Cohn M . Cellular response to DNA interstrand crosslinks: the Fanconi anemia pathway. Cell Mol Life Sci. 2016; 73(16):3097-114. PMC: 4951507. DOI: 10.1007/s00018-016-2218-x. View

Wilson M, Jiang Y, Villalta P, Stornetta A, Boudreau P, Carra A . The human gut bacterial genotoxin colibactin alkylates DNA. Science. 2019; 363(6428). PMC: 6407708. DOI: 10.1126/science.aar7785. View

Hemphill A, Bruun D, Thrun L, Akkari Y, Torimaru Y, Hejna K . Mammalian SNM1 is required for genome stability. Mol Genet Metab. 2008; 94(1):38-45. PMC: 2413150. DOI: 10.1016/j.ymgme.2007.11.012. View

Dronkert M, de Wit J, Boeve M, Vasconcelos M, van Steeg H, Tan T . Disruption of mouse SNM1 causes increased sensitivity to the DNA interstrand cross-linking agent mitomycin C. Mol Cell Biol. 2000; 20(13):4553-61. PMC: 85844. DOI: 10.1128/MCB.20.13.4553-4561.2000. View

Mandel C, Kaneko S, Zhang H, Gebauer D, Vethantham V, Manley J . Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease. Nature. 2006; 444(7121):953-6. PMC: 3866582. DOI: 10.1038/nature05363. View

Madi A, Fisher D, Maughan T, Colley J, Meade A, Maynard J . Pharmacogenetic analyses of 2183 patients with advanced colorectal cancer; potential role for common dihydropyrimidine dehydrogenase variants in toxicity to chemotherapy. Eur J Cancer. 2018; 102:31-39. DOI: 10.1016/j.ejca.2018.07.009. View

Zhang X, Richie C, Legerski R . Translation of hSNM1 is mediated by an internal ribosome entry site that upregulates expression during mitosis. DNA Repair (Amst). 2003; 1(5):379-90. View

10.

Lake R, Fan H . Structure, function and regulation of CSB: a multi-talented gymnast. Mech Ageing Dev. 2013; 134(5-6):202-11. PMC: 3750219. DOI: 10.1016/j.mad.2013.02.004. View

11.

Schultz L, Chehab N, Malikzay A, Halazonetis T . p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks. J Cell Biol. 2001; 151(7):1381-90. PMC: 2150674. DOI: 10.1083/jcb.151.7.1381. View

12.

Fagerberg L, Hallstrom B, Oksvold P, Kampf C, Djureinovic D, Odeberg J . Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics. Mol Cell Proteomics. 2013; 13(2):397-406. PMC: 3916642. DOI: 10.1074/mcp.M113.035600. View

13.

Knipscheer P, Raschle M, Smogorzewska A, Enoiu M, Ho T, Scharer O . The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair. Science. 2009; 326(5960):1698-701. PMC: 2909596. DOI: 10.1126/science.1182372. View

14.

Ruhland A, Haase E, Siede W, Brendel M . Isolation of yeast mutants sensitive to the bifunctional alkylating agent nitrogen mustard. Mol Gen Genet. 1981; 181(3):346-51. DOI: 10.1007/BF00425609. View

15.

Henriques J, MOUSTACCHI E . Interactions between mutations for sensitivity to psoralen photoaddition (pso) and to radiation (rad) in Saccharomyces cerevisiae. J Bacteriol. 1981; 148(1):248-56. PMC: 216187. DOI: 10.1128/jb.148.1.248-256.1981. View

16.

Semlow D, Zhang J, Budzowska M, Drohat A, Walter J . Replication-Dependent Unhooking of DNA Interstrand Cross-Links by the NEIL3 Glycosylase. Cell. 2016; 167(2):498-511.e14. PMC: 5237264. DOI: 10.1016/j.cell.2016.09.008. View

17.

Betous R, Goullet de Rugy T, Pelegrini A, Queille S, de Villartay J, Hoffmann J . DNA replication stress triggers rapid DNA replication fork breakage by Artemis and XPF. PLoS Genet. 2018; 14(7):e1007541. PMC: 6085069. DOI: 10.1371/journal.pgen.1007541. View

18.

Wang X, Wang S, Zhou L, Yu L, Zhang L . A network-pathway based module identification for predicting the prognosis of ovarian cancer patients. J Ovarian Res. 2016; 9(1):73. PMC: 5093979. DOI: 10.1186/s13048-016-0285-0. View

19.

Li X, Hejna J, Moses R . The yeast Snm1 protein is a DNA 5'-exonuclease. DNA Repair (Amst). 2004; 4(2):163-70. DOI: 10.1016/j.dnarep.2004.08.012. View

20.

Ahkter S, Richie C, Zhang N, Behringer R, Zhu C, Legerski R . Snm1-deficient mice exhibit accelerated tumorigenesis and susceptibility to infection. Mol Cell Biol. 2005; 25(22):10071-8. PMC: 1280277. DOI: 10.1128/MCB.25.22.10071-10078.2005. View