Endoplasmic Reticulum Stress in Bone Metastases

Overview

Journal Front Oncol

Specialty Oncology

Date 2020 Aug 28

PMID 32850317

Citations 4

Authors

Longyong Xu

Weijie Zhang

Xiang H-F Zhang

Xi Chen

Affiliations

Soon will be listed here.

Abstract

Metastases-the spreading of cancer cells from primary tumors to distant organs, including bone-is often incurable and is the major cause of morbidity in cancer patients. Understanding how cancer cells acquire the ability to colonize to bone and become overt metastases is critical to identify new therapeutic targets and develop new therapies against bone metastases. Recent reports indicate that the endoplasmic reticulum (ER) stress and, as its consequence, the unfolded protein response (UPR) is activated during metastatic dissemination. However, their roles in this process remain largely unknown. In this review, we discuss the recent progress on evaluating the tumorigenic, immunoregulatory and metastatic effects of ER stress and the UPR on bone metastases. We explore new opportunities to translate this knowledge into potential therapeutic strategies for patients with bone metastases.

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