Genetic Analysis of the Coronavirus SARS-CoV-2 Host Protease in Different Populations

Overview

Journal Front Genet

Date 2020 Aug 28

PMID 32849840

Citations 38

Authors

Roberta Russo

Immacolata Andolfo

Vito Alessandro Lasorsa

Achille Iolascon

Mario Capasso

Affiliations

Soon will be listed here.

Citing Articles

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References

Ghosh R, Oak N, Plon S . Evaluation of in silico algorithms for use with ACMG/AMP clinical variant interpretation guidelines. Genome Biol. 2017; 18(1):225. PMC: 5704597. DOI: 10.1186/s13059-017-1353-5. View

Ellinghaus D, Degenhardt F, Bujanda L, Buti M, Albillos A, Invernizzi P . Genomewide Association Study of Severe Covid-19 with Respiratory Failure. N Engl J Med. 2020; 383(16):1522-1534. PMC: 7315890. DOI: 10.1056/NEJMoa2020283. View

Wang C, Horby P, Hayden F, Gao G . A novel coronavirus outbreak of global health concern. Lancet. 2020; 395(10223):470-473. PMC: 7135038. DOI: 10.1016/S0140-6736(20)30185-9. View

Zhu N, Zhang D, Wang W, Li X, Yang B, Song J . A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med. 2020; 382(8):727-733. PMC: 7092803. DOI: 10.1056/NEJMoa2001017. View

Russo R, Andolfo I, Lasorsa V, Iolascon A, Capasso M . Genetic Analysis of the Coronavirus SARS-CoV-2 Host Protease in Different Populations. Front Genet. 2020; 11:872. PMC: 7417663. DOI: 10.3389/fgene.2020.00872. View

Kawase M, Shirato K, van der Hoek L, Taguchi F, Matsuyama S . Simultaneous treatment of human bronchial epithelial cells with serine and cysteine protease inhibitors prevents severe acute respiratory syndrome coronavirus entry. J Virol. 2012; 86(12):6537-45. PMC: 3393535. DOI: 10.1128/JVI.00094-12. View

Sajuthi S, DeFord P, Li Y, Jackson N, Montgomery M, Everman J . Type 2 and interferon inflammation regulate SARS-CoV-2 entry factor expression in the airway epithelium. Nat Commun. 2020; 11(1):5139. PMC: 7550582. DOI: 10.1038/s41467-020-18781-2. View

Darbani B . The Expression and Polymorphism of Entry Machinery for COVID-19 in Human: Juxtaposing Population Groups, Gender, and Different Tissues. Int J Environ Res Public Health. 2020; 17(10). PMC: 7277542. DOI: 10.3390/ijerph17103433. View

Glowacka I, Bertram S, Muller M, Allen P, Soilleux E, Pfefferle S . Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response. J Virol. 2011; 85(9):4122-34. PMC: 3126222. DOI: 10.1128/JVI.02232-10. View

10.

Zhou Y, Vedantham P, Lu K, Agudelo J, Carrion Jr R, Nunneley J . Protease inhibitors targeting coronavirus and filovirus entry. Antiviral Res. 2015; 116:76-84. PMC: 4774534. DOI: 10.1016/j.antiviral.2015.01.011. View

11.

Bertram S, Heurich A, Lavender H, Gierer S, Danisch S, Perin P . Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts. PLoS One. 2012; 7(4):e35876. PMC: 3340400. DOI: 10.1371/journal.pone.0035876. View

12.

Pareek M, Bangash M, Pareek N, Pan D, Sze S, Minhas J . Ethnicity and COVID-19: an urgent public health research priority. Lancet. 2020; 395(10234):1421-1422. PMC: 7173801. DOI: 10.1016/S0140-6736(20)30922-3. View

13.

Iwata-Yoshikawa N, Okamura T, Shimizu Y, Hasegawa H, Takeda M, Nagata N . TMPRSS2 Contributes to Virus Spread and Immunopathology in the Airways of Murine Models after Coronavirus Infection. J Virol. 2019; 93(6). PMC: 6401451. DOI: 10.1128/JVI.01815-18. View

14.

Hoffmann M, Kleine-Weber H, Schroeder S, Kruger N, Herrler T, Erichsen S . SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020; 181(2):271-280.e8. PMC: 7102627. DOI: 10.1016/j.cell.2020.02.052. View

15.

Benetti E, Tita R, Spiga O, Ciolfi A, Birolo G, Bruselles A . ACE2 gene variants may underlie interindividual variability and susceptibility to COVID-19 in the Italian population. Eur J Hum Genet. 2020; 28(11):1602-1614. PMC: 7366459. DOI: 10.1038/s41431-020-0691-z. View

16.

Cao Y, Li L, Feng Z, Wan S, Huang P, Sun X . Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations. Cell Discov. 2020; 6:11. PMC: 7040011. DOI: 10.1038/s41421-020-0147-1. View

17.

Devaux C, Rolain J, Raoult D . ACE2 receptor polymorphism: Susceptibility to SARS-CoV-2, hypertension, multi-organ failure, and COVID-19 disease outcome. J Microbiol Immunol Infect. 2020; 53(3):425-435. PMC: 7201239. DOI: 10.1016/j.jmii.2020.04.015. View

18.

Uno Y . Camostat mesilate therapy for COVID-19. Intern Emerg Med. 2020; 15(8):1577-1578. PMC: 7188520. DOI: 10.1007/s11739-020-02345-9. View

19.

Ziegler C, Allon S, Nyquist S, Mbano I, Miao V, Tzouanas C . SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues. Cell. 2020; 181(5):1016-1035.e19. PMC: 7252096. DOI: 10.1016/j.cell.2020.04.035. View

20.

Schuler B, Habermann A, Plosa E, Taylor C, Jetter C, Kapp M . Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 infection in the lung epithelium. bioRxiv. 2020; . PMC: 7263492. DOI: 10.1101/2020.05.22.111187. View